Purpose: To evaluate the protective effect of cavidine against asthma in neonatal mice.
 Methods: Neonatal mice were treated with at doses 5 and 10 mg/kg, po, 2 h prior to induction ovalbumin (OVA) on 1st 14th days treatment protocol. The anti-asthma activity was evaluated by determining number inflammatory cells cytokine levels broncho-alveolar lavage fluid (BALF) OVA-specific IgE TGF-β 1...

Within the family Poeciliidae, a wide range of adaptations accompanying viviparity has evolved. The reproductive mechanisms of five representative species were examined and related to the habitats in which they are employed. Poecilia reticulata, the guppy, represents the majority of poeciliids which have a single stage of embryos in the ovary at a time. Most of the nutrients are prepack-aged in...

Background and objectives Wheat gluten (WG) often co-exists with egg white (EW) whey proteins in foods. This study investigated the impact of WG on denaturation hen (S-)ovalbumin [(S-)OVA], lysozyme (LYS), bovine serum albumin (BSA). Findings caused peak temperature LYS BSA to increase that (S-)OVA decrease. It accelerated decelerated OVA, respectively, their lowered activation energy. In contr...

Allergic airway inflammation is attenuated by oral tolerization (oral exposure to allergen, followed by conventional sensitization and challenge with homologous antigen), which decreases airway allergen challenge-induced eosinophilic infiltration of the lungs and bone marrow eosinophilia. We examined its effects on bone marrow eosinophil and neutrophil production. Mice of wild type (BP-2, BALB/...

Background: The events that trigger type 2 immune responses are not well characterized. Given the central role of sweat in maintaining skin hydration, sweating disturbance at points allergen entry would predispose to food sensitization. A previous study demonstrated epicutaneously applied hapten more readily penetrates stratum corneum with a lower water content than higher water. Thus, is likel...

Wimalawansa et al., "Nitric Oxide Donor Alleviates Ova riectomy-Induced Bone Loss,” Bone, 18(4):301-304, 1996. Wimalawansa et al., “Replacement Therapy with Nitric Oxide or Nitric Oxide Dornor In Vivo, Maintains the Bone Mass in Rats After Ovariectomy,” World congress On Osteopororis, Abstract No. PTU 759, Amsterdam, May 18–23, 1996. Wimalawansa, “Steroid-Induced Osteoporosis can be Pre vented ...

The intent of this article is to review protease inhibitors produced from a diversity of animals including cnidarians, annelids, insects, crustaceans, mollusks, fish, amphibians, reptiles and mammals. They can be isolated from various tissues including pancreas, ova, liver, seminal plasma, serum, venom, skin secretion, hemolymph and salivary glands. Animal protease inhibitors display a variety ...

BACKGROUND Modified vaccinia virus Ankara (MVA)-encoding antigens are considered as safe vaccine candidates for various infectious diseases in humans. Here, we investigated the immune-modulating properties of MVA-encoding ovalbumin (MVA-OVA) on the allergen-specific immune response. METHODS The immune-modulating properties of MVA-OVA were investigated using GM-CSF-differentiated BMDCs from C5...

Objective(s): Human and animal studies have shown a close relationship between obesity and asthma severity. Here, we examined the effects of diet-induced obesity (DIO) on the expression levels of IL-1β, IRAK-1 and TRAF-6 mRNA in male Wistar rats tracheal after sensitization with ovalbumin (OVA). Materials and Methods:Twenty male Wistar rats divided to four groups, included, control group with ...