We have studied six patients who had undergone mitral valve replacement. Estimations of cardiac output and of pulmonary vascular resistance were made, beginning two hours after the finish of the operation. Glucagon, 10 mg, was given intravenously, and cardiac output and pulmonary vascular resistance were measured 5 minutes and 30 minutes later. In all six cases there was a significant decrease ...

THE INCREASING clinical use of hexamethonium, a ganglion blocking agent, makes desirable a detailed knowledge of its acute hemodynamic effects in normotensive man. Recent work on dogs' indicates that the hexamethonium-induced fall in arterial pressure is accompanied by significant decrease in cardiac output with increase in the calculated total peripheral resistance. Accordingly, the authors co...

HARAKAL, CONCETTA,MARCUS M. REIDENBERG,ROGER W. SEW, AND EDWIN A. OHLER. Hemodynamic effects of adrenal medullectomy in the dog. Am. J. Physiol. 210(r): 5-6. I g66.-Adrenal medullas were successfully removed from dogs leaving intact, functioning adrenal cortical tissue on one side. Following medullectomy there was a decrease in cardiac output and an increase in total peripheral resistance, but ...

At cardiac catheterization, the effect of isoproterenol on coronary blood flow was compared in six patients with normal coronary arteries and normal left ventricular function, and eight patients with angiographically defined coronary lesions. Coronary blood flow was measured by selective coronary artery injection of xenon-133 and external monitoring of disappearance curves with a dual probe, di...

SUMMARY Measurement of systemic vascular resistance in man currently requires arterial and venous cannulation, so that cardiac output and mean arterial blood pressure may be simultaneously determined. This report describes a noninvasive technic for determining systemic vascular resistance (SVR.), utilizing an ultrasonic method for cardiac output measurement, and a combination of sphygmomanometr...

We propose two identification algorithms for quantitating the total peripheral resistance (TPR) baroreflex, an important contributor to short-term arterial blood pressure (ABP) regulation. Each algorithm analyzes beat-to-beat fluctuations in ABP and cardiac output, which may both be obtained noninvasively in humans. For a theoretical evaluation, we applied both algorithms to a realistic cardiov...