Otosclerosis is an inflammatory disease of the human temporal bone which was assumed to affect up to 10% of the Caucasians. Histologic otosclerosis has an incidence of 3.4%. It is considered as a major cause of hearing loss in Western countries while a low incidence is observed among Africans. Many hypotheses about its origin had been formulated in the past. Otosclerosis genes (OTSC1-5) and col...

Introduction Observing the obliquity of stapes by closely scrutinizing the HRCT temporal bone in otosclerosis revealed a reliable and consistent finding. This finding can add to the existing radiological criteria in diagnosis of otosclerosis. Objective The objective of this study is to establish the obliquity of stapes in otosclerosis by radiological measurements using HRCT temporal bone by com...

Objective: Otosclerosis has long been a clinical, audiological and tympanometric diagnosis. The definitive role and value of imaging is yet unclear in the clinical practice. In this work we aimed to study the temporal bone density using CT scan in patients clinically diagnosed as otosclerosis, not only to ascertain the value of CT scan, but also to study the correlation between the bone density...

Abstract Purpose of Review To summarize and critically review recent literature on the relative cost-effectiveness hearing augmentation versus stapes surgery for treatment otosclerosis. Recent Findings Otosclerosis leads to reduced patient quality life, which can be ameliorated by either surgery, or aid usage. The success is high, risks serious postoperative complications are low. Hearing aids ...

Clinical otosclerosis (OMIM 166800/605727) has a prevalence of 0.2-1% among white adults, making it the single most common cause of hearing impairment in this group. It is caused by abnormal bone homeostasis of the otic capsule with the consequent development of sclerotic foci that invade the stapedio-vestibular joint (oval window) interfering with free motion of the stapes. Impaired ossicular ...

Objective To assess long-term hearing outcomes in patients treated with third-generation bisphosphonates for otosclerosis-related progressive sensorineural hearing loss (SNHL). Study Design Retrospective case series review. Methods We performed a retrospective case series review of patients with otosclerosis and progressive SNHL. Patients were treated with either risedronate or zoledronate ...

AIM To determine the sensitivity and specificity of high resolution computed tomography (HRCT) in the diagnosis of otosclerosis. METHODS A systematic literature review was undertaken to include Level I-III studies (Oxford Centre for Evidenced based Medicine) that utilised HRCT to detect histology confirmed otosclerosis. Quantitative synthesis was then performed. RESULTS Based on available l...

BACKGROUND The aim of this prospective clinical study was to evaluate the clinical importance of Vestibular-Evoked Myogenic Potentials (VEMPs) in the assessment and differential diagnosis of otosclerosis and otologic diseases characterized by "pseudo-conductive" components. We also investigated the clinical appearance of balance disorders in patients with otosclerosis by correlating VEMP result...

This critical review examines whether multifrequency tympanometry is more effective than standard tympanometry for detecting otosclerosis in adults with middle ear disorders. Study designs included: one Non-randomized Clinical Trial(between and within groups), four Non-randomized Clinical TrialMixed (between). Overall, the evidence indicates that multifrequency tympanometry provides a more effi...