We report on a patient who had recurrent skeletal dysplasia in three of four of her pregnancies which all resulted in termination of pregnancies. The ultrasound and / or histological findings of her first and fourth pregnancy were suggestive of osteogenesis imperfecta while those in her second pregnancy were more suggestive of achondrogenesis. The exact diagnosis could not be made clinically at...

introduction: the objective of this study was to evaluated effect of retinoic acid (ra) on the tibia osteogenesis in the chick embryos. materials and methods: for this purpose 0.75mg ra dissolved in 2ml dimthylsulfoxide (dmso) was droped on the limb bud of chick embryos at sixth day of incubation. the osteogenesis of tibia in ra-treated embryos were compared with normal control and dmso-treated...

purpose: congenital third nerve palsy was generally thought to exist in isolation without associated abnormalities. in this report, we present a case of congenital third nerve palsy in osteogenesis imperfecta. methods: a 6-month-old girl with osteogenesis imperfceta presented with ptosis and large incomitant exotropia in left eye (le) at birth. ocular examination revealed total third nerve pals...

We report a new case of osteogenesis imperfecta (OI) type II which is a perinatal lethal form. First trimester ultrasound didn't identified abnormalities. Second trimester ultrasound showed incurved limbs, narrow chest, with hypomineralization and multiple fractures of ribs and long bones. Parents refused pregnancy termination; they felt that the diagnosis was late. At birth, the newborn presen...