Anterior cervical discectomy and fusion (ACDF) has been performed for degenerative and traumatic cervical diseases to improve pain and neurologic symptoms including sensory change and motor weakness. Infection, however, is a rare complication of ACDF, and late infection is even much rarer. We present a case of late Infection from ACDF C4-5 using Biocompatible Osteoconductive Polymer (BOP) after...

The integration of orthopedic implants with host bone presents a major challenge in joint arthroplasty, spinal fusion and tumor reconstruction. The cellular microenvironment can be programmed via implant surface functionalization allowing direct modulation of osteoblast adhesion, proliferation, and differentiation at the implant--bone interface. The development of layer-by-layer assembled polye...

Repair of large oral bone defects such as vertical alveolar ridge augmentation could benefit from the rapidly developing additive manufacturing technology used to create personalized osteoconductive devices made porous tricalcium phosphate/hydroxyapatite (TCP/HA)-based bioceramics. These can be also hydrogel carriers improve their osteogenic potential. However, TCP/HA constructs are prone britt...

Nowadays, artificial implants, a third denture of human, can maximize the chewing efficiency of patients with missing teeth, delay the absorption of alveolar bone and improve the quality of life. Osseointegration of the interface between the bone and implants, introduced first by Branemark et al. [1,2], is the most determining factor in oral clinical implant applications. As the main material i...

There are four characteristics that an ideal bone graft material should exhibit which include: (i) osteointegration, the ability to chemically bond to the surface of bone without an intervening layer of fibrous tissue;1 (ii) osteoconduction, the ability to support the growth of bone over its surface;1 (iii) osteoinduction, the ability to induce differentiation of pluripotential stem cells from ...

Here, we show the importance of the marine biomaterial chitin and its derivative, chitosan, in bioimplant applications. Titanium and titanium alloys have shown high potential for load bearing in bioimplant applications. However, after their application, a bond with living bone often does not develop or the integration of the implants with bone tissue takes several months. Moreover, the surface ...