Objective(s): Osteoarthritis (OA), as a known degenerative joint disease, is the most common form of arthritis. In this study, we aimed to elucidate unclear pathogenesis of OA. Materials and Methods: Rabbit models of OA were established by the transection of the anterior cruciate ligament. Rabbits were randomly divided into three equal groups: the experimental group (OA modeling, treated with e...

Background: Due to the obvious differences in the natural course of rheumatoid arthritis (RA) and osteoarthritis (OA),different functional outcomes might be expected after Total Knee Arthroplasty (TKA) in these distinct patients. Althoughseveral studies have reported the objective outcome of TKA in RA and OA patients, few studies have compared postoperativepatient-satisfaction levels.Methods: I...

In this paper we compare the prevalence of osteoarthritis (OA) of hip and knee joints on skeletons series and relations between them. OA was registered from 166 individuals of Neolithic and protohistorical periods. Between Neolithic and Iron Age periods the ratio [hip OA/ knee OA] increases with diminution of knee OA prevalence; the ratio [patello-femoral OA / tibio-femoral OA] rather tends to ...

Osteoarthritis (OA) is the most common degenerative joint disease that causes chronic pain and disability. Different innate immune components, including macrophages, T cells, neutrophils, participate in OA pathophysiology. Neutrophils are abundant circulating leukocytes with multiple specialized functions contributing to adaptive functions. Although neutrophils produce proinflammatory cytokines...

BACKGROUND Early diagnosis of osteoarthritis (OA) is essential for preventing further cartilage destruction and decreasing severe complications. The aims of this study are to explore the relationship between OA pathological grades and quantitative acoustic parameters and to provide more objective criteria for ultrasonic microscopic evaluation of the OA cartilage. METHODS Articular cartilage s...

Background: To study if patients that have a second radiograph 2 or more years after nonoperative treatment of an isolated radial head fracture have radiocapitellar osteoarthritis (RC OA). Methods: We used the database of 3 academic hospitals in one health system from 1988 to 2013 to find patients with isolated radial head fractures (no associated ligament injury or fracture) that had a second ...

Objective: Osteoarthritis (OA) is one of the prevalent and degenerative disorders of the joints that cause significant pain and functional disability. It is a disease in which not only the articular cartilage of the synovial joint is affected but also the adjacent bone, ligaments, capsule, synovial membrane and even peri-articular muscles are distressed. Worldwide 630 million people or 15% popu...

Epidemiological studies correlate low levels of vitamin D with the osteoarthritis (OA) progression. Cytokines and metalloproteases play a major role in OA promoting the inflammation and degradation of the cartilage and can be induced through the Toll-like receptor (TLR) pathway. The aim of this study was to evaluate the protective effect of vitamin D supplementation on the development of osteoa...

background knee osteoarthritis (oa) is a common joint disease and several different physiotherapy protocols have been recommended to provide pain relief and improve disability in patients with knee oa. objectives in order to find the effectiveness of local vibration application on knee oa complications, a randomized controlled clinical trial was designed to assess the changes in muscle torque, ...

OBJECTIVE An attempt to define pre-osteoarthritis (OA) versus early OA and definitive osteoarthritis. METHODS A group of specialists in the field of cartilage science and treatment was formed to consider the nature of OA onset and its possible diagnosis. RESULTS Late-stage OA, necessitating total joint replacement, is the end stage of a biological process, with many previous earlier stages....