OBJECTIVE The aim of this study was to assess the anxiety, depression, and serum cortisol level in OSMF patients. MATERIALS AND METHODS This cross-sectional study was conducted in the Outpatient Department of Oral Medicine and Radiology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India. Age- and gender-matched 105 patients were divided into three equal ...

BACKGROUND Oral submucous fibrosis (OSMF) is a chronic insidious disease of the oral mucosa, commonly seen in South East Asia. It occurs mainly due to the habit of quid or gutkha chewing. There is a clear dose dependent relationship between gutkha chewing and development of OSMF, also due to continuous chewing for larger intervals of time unnecessary forces are exerted on the muscles mainly the...

Background: Oral submucous fibrosis(OSMF) is a potentially malignant disorder (PMDs) with characteristic epithelial and connective tissue changes regarded as possessing high degree of potential. Epithelial dysplasia an important marker development from PMDs. Because agreement among oral pathologists poor regarding lesional diagnosis, Ki-67 proliferative may have place in objectively characteriz...

Aim: To analyze serum uric acid, urea, and creatinine levels in Oral Submucous Fibrosis patients and compare them with those of healthy controls. Materials and Methods: 40 OSMF patients and 20 controls had serum uric acid, urea and creatinine levels measured using spectrophotometer. The data obtained was analyzed using the Statistical Package for the Social Sciences, version 19.0 (SPSS 19). Sta...

CONTEXT Palm prints formed once does not change throughout life and is not influenced by environment. Palmar Dermatoglyphics can indicate the development of potentially malignant and malignant lesions and help in identifying persons at high risk of developing Oral submucous fibrosis (OSMF) and Oral squamous cell carcinoma (OSSC). AIM To analyze the qualitative [finger ridge pattern and presen...

Oral submucous fibrosis (OSMF) is a potentially malignant oral condition effectively linked to the causative habit of chewing areca nut. Since its first description in the 1950s, numerous epidemiological, biochemical, histological, and genetic studies have been reported. While most studies point out to the cause and effect of areca nut, co-additive factors are also implicated in the progression...

Background: Biotransformation plays a crucial role in carcinogen activity. Genetic polymorphisms in xenobiotic metabolising enzymes crucial to carcinogen and drug metabolism and lead to variations in their activity. These enzymes increase the risk of cancer by an altered action on environmental carcinogens. Tobacco abuse is a well‐known risk factor for potentially malignant disorders. Factors t...

Oral submucous fibrosis (OSMF) is a chronic, insidious and disabling condition affecting the oral cavity, being especially prevalent in India and South East Asia. However, considering its high prevalence and potential to undergo malignant transformation, OSMF has not been widely investigated with respect to levels of antioxidants, especially beta carotene. In the present study, an attempt was m...

OBJECTIVE Oral submucous fibrosis (OSMF) is a premalignant condition of oral cavity characterized by inflammation and progressive mucosal fibrosis. It has questionable pathogenesis. Mast cells (MC) have been associated with variety of inflammatory and fibrotic conditions, but little is known about their role in OSMF. Mast cells have been studied in normal gingiva, chronic inflammatory gingiviti...

Aim: The role of blood cholesterol level variations in diagnosis and treatment has been extensively worked on in many studies. However, studies on alteration in serum lipid profile among OSMF patients are limited. The present study was performed to estimate serum lipid profile in OSMF patients and gutkha chewers. Material and Methods: The study sample comprised of 45 cases, which included 15 cl...