A detailed investigation of Valsartan`s light-induced degradation is reported. Based on UPLC-HRMS studies stressed solutions several pathways are proposed. Some the proposed structures were obtained by forced experiments. Examination analytical data including crystal allowed for structural revision one literature-known degradant. In addition, irradiation under aerobic conditions revealed furthe...

Organic dust and related microbial exposures are the main inducers of several respiratory symptoms. Occupational exposure to organic dust is very common and has been reported in diverse settings. In vitro tests using relevant cell cultures can be very useful for characterizing the toxicity of complex mixtures present in the air of occupational environments such as organic dust. In this study, t...

Abstract Background Tuberculosis is an infection that has high mortality rate in human as well animals if it remains unattained for long time. Scientists are always desirous to discover new molecules against Mycobacterium tuberculosis ; one of them bedaquiline which was recently approved treat multidrug resistance TB. During the clinical study molecule stability and impurity key aspects develop...

Labeling a food as “organic” entails a claim about its production but is silent on its calorie content. Nevertheless, people infer that organic cookies are lower in calories and can be eaten more often than conventional cookies (Study 1). These inferences are observed even when the nutrition label conveys identical calorie content and are more pronounced among perceivers high on pro-environment...

Abstract Under different concentrations of the base potassium deuteroxide KOD, progress reactions, such as enolization, D‐substitution, isomerization, and conformational changes diketopiperazine cyclo(L‐Pro‐L‐Xxx) cyclo(D‐Pro‐L‐Xxx) (Xxx = Phe, Tyr) in D 2 O solution, was investigated by 1 H nuclear magnetic resonance (NMR). Cyclo(L‐Pro‐L‐Xxx) is mostly isomerized to whereas only slightly even ...

The purpose of this study was to compare the effect and toxicity of organic selenium (Pro-Se) with inorganic selenium (IOSe) in preventing asthma in ovalbumin-induced asthmatic mice. After the mice were treated orally with Pro-Se and IOSe, respectively, the plasma Se levels, Se accumulation in liver and kidney, tumor necrosis factor alpha (TNF- α ), interleukin 1 beta (IL-1 β ), oxidative stres...

japan, known as a pro-choice country in terms of abortion, is currently facing the increase of “selective abortions” thanks to new prenatal screening. efforts to restrict proliferation of new technology has not been successful and it is likely that japan will turn pro-life by strictly enforcing the maternity protection act (mpa), which prohibits abortions due to “fetal cause”.

A small organic molecule, Pro-NH(2), catalyzing the enantioselective aldol reaction "in water" not merely "in the presence of water" with good enantioselectivity has been discovered for the first time.