Title Page 5-hydroxytryptamine mediated neurotransmission modulates spontaneous and vagal evoked glutamate release in the nucleus tractus solitary (NTS)-effect of uptake blockade This article has not been copyedited and formatted. The final version may differ from this version. Abstract The effect of blockade of either 5-HT/serotonin transporter (5-HTT/SERT) with citalopram or the organic catio...

Recently, a polyspecific organic cation transporter, hOCT1, was cloned from human liver. To date, limited studies examining the functional characteristics of the transporter have been performed. The purpose of the present study was to develop a mammalian expression system for hOCT1 and to characterize the interactions of various compounds with the cloned transporter. Lipofection was used to tra...

This review summarizes published in vitro, animal, and clinical studies investigating the effects of green tea (Camellia sinensis) extract and associated catechins on drug-metabolizing enzymes and drug transporters. In vitro studies suggest that green tea extract and its main catechin, (-)-epigallocatechin-3-gallate, to varying degrees, inhibit the activity of CYP1A1, CYP1A2, CYP2B6, CYP2C8, CY...

  Affinity of different organs for verapamil is highly variable and organ-specific. For example, the drug exhibits high levels of accumulation in lung tissues. A transporter recognising verapamil as a substrate has previously been identified in human retinal pigment epithelial (RPE) and in rat retinal capillary endothelial (TR-iBRB2) cells. This transporter is distinct from any of the cloned or...

Cloning of the Rabbit Organic Cation Transporter, rbOCT2, and Functional Comparisons with rbOCT1. Am J. Physiol. Renal Physiol. Multiple organic cation (OC) transporters are present in rabbit kidney and may play different functional roles. We cloned rbOCT2 and compared its function with that of rbOCT1. In transiently transfected COS-7 cells, rbOCT1 and rbOCT2 mediated uptake of [ 3 H]tetraethyl...