Anti-desmoglein 3 and 1 autoantibodies are involved in the pathogenesis of pemphigus diseases. Our objective was to assess the value of ELISA in the diagnosis of pemphigus and its correlation with the severity of pemphigus vulgaris. Based on clinical presentation and histopathologic confirmation for the diagnosis of the pemphigus, 38 patients took part in the study. Sera of the patients were te...

indirect immunofluorescence (iif) has been used to identify and measure autoantibody levels in pemphigus vulgaris but data about relationship between clinical severity of disease and antibody titers by iif have been conflicting. we conducted this cross-sectional study to correlate the severity of oral and/or cutaneous involvement in patients with pemphigus vulgaris based on pemphigus area and a...

background and aims. pemphigus is a chronic autoimmune and vesiculobollous disease that can affect skin and different mucous membrane surfaces. primary manifestations occur in oral cavity in almost 60% of cases. the purpose of the present study was to evaluate the epidemiology of pemphigus in tehran, iran in a 20-year period. materials and methods. a retrospective study was conducted on the rec...

BACKGROUND Corticosteroids are the systemic treatment of choice in patients with pemphigus vulgaris, but chronic administration is associated with side effects. Intravenous treatment with cyclophosphamide can improve the clinical signs of pemphigus vulgaris. MATERIAL AND METHODS We prospectively studied 8 patients diagnosed with pemphigus vulgaris. Six of these had mucocutaneous pemphigus vul...

discussion we have to stress that the importance of this case report is its presentation in an elderly patient, as the frequent age of presentation in the iranian patients is the middle age. on the other hand, pv occurs rarely, thus, the reporting of any rare case with some exceptions is important. case presentation we reported a case of pemphigus vulgaris in a 79-year-old patient with the exte...

Background: Pemphigus vulgaris has an obscure etiology; the presence of autoantibodies is coherent with autoimmune disease. Rituximab a monoclonal antibody that specifically targets CD20 antigen B lymphocytes, arisen as novel treatment approach for pemphigus vulgaris. Case presentation: A 39-year-old male patient presented three-month history mouth ulcers, poor oral hygiene accompanied heavy to...

OBJECTIVE The purpose of the study was to evaluate the clinical presentation of pemphigus vulgaris in the oral cavity. STUDY DESIGN A retrospective study of 71 cases of pemphigus vulgaris obtained over a period of 7 years from 1st January 2001 to 31st December 2007 in the Department of Oral Pathology, Government Dental College and Department of Dermatology, Government Medical College, Calicut...

Background. Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. In 50 to 70% of cases, the initial manifestations of pemphigus vulgaris are oral lesions which may be followed by skin lesions. But it is unusual for the disease to present with initial and solitary persistent lower lip lesions without progression to any other location. Main Observations. ...

BACKGROUND There are two main clinical subsets of pemphigus: pemphigus vulgaris and pemphigus foliaceus. Clinical and epidemiological changes related to both types of pemphigus have been observed in the last years. OBJECTIVES To analyze a 21-year historical case series of pemphigus vulgaris and pemphigus foliaceus in the northeast region of the state of Sao Paulo, where pemphigus foliaceus is...

Aim: The aim of this case presentation was to highlight the importance awareness two different coexisting pathologies, as well emphasise that early diagnosis and prompt management are essential manage pemphigus vulgaris. Pemphigus vulgaris is a rare, life-threatening autoimmune disease characterised by presence blisters on surface oral mucosa caused antibodies against adhesion molecules cell ke...