objective: the present study aimed to compare the value of ibuprofen and fennel for postpartum pain relief in women with normal vaginal delivery. materials and methods: in this randomized clinical trial we studied 90 women referring to obstetrics ward for normal vaginal delivery (nvd) in assali hospital in khoramabad. women were randomly allocated to receive either oral ibuprofen or oral fennel...

We tested the hypothesis that the shift in the cutaneous vasodilator response to hyperthermia seen with elevated female reproductive hormones is a prostaglandin-dependent resetting of thermoregulation to higher internal temperatures, similar to that seen in the febrile response to bacterial infection. Using water-perfused suits to control body temperature, we conducted heat stress experiments i...

Although intravenous indomethacin and ibuprofen are widely used for closure of patent ductus arteriosus in premature infants, these formulations are unavailable in the Islamic Republic of Iran. In this study of the therapeutic effects of oral treatments, 20 preterm infants were randomized to oral ibuprofen (1 x 10 mg/kg, then 2 x 5 mg/kg at 24-hour intervals) or oral indomethacin (3 x 0.2 mg/kg...

BACKGROUND AND OBJECTIVES Previously published studies have suggested the lack of a pharmacokinetic interaction between ibuprofen and paracetamol when they are delivered as a fixed-dose oral combination. The aim of this study was to determine the pharmacokinetic profile and safety of a fixed-dose intravenous (IV) combination, containing 3 mg/mL ibuprofen and 10 mg/mL paracetamol, in comparison ...

BackgroundA patent ductus arteriosus (PDA), resulting in hemodynamically-significant left to right shunting of blood, increases complications and mortality in premature infants. PDA in premature infants is conventionally treated by intravenous indomethacin. Intravenous ibuprofen was recently shown to be as effective, but to have adverse reactions in premature infants. If equally effective, then...

BACKGROUND Severe pulmonary hypertension may following ibuprofen administration for ductal closure. CASE CHARACTERISTICS An extremely preterm infant who developed severe pulmonary hypertension unresponsive to inhaled nitric oxide after ibuprofen administration. OUTCOME Pulmonary hypertension reversed after the administration of oral sildenafil, but the infant died due to complications relat...

OBJECTIVE Patent ductus arteriosus (PDA), a common finding among premature infants, is conventionally treated by intravenous indomethacin. Intravenous ibuprofen was recently shown to be as effective and to have fewer adverse reactions in preterm infants. If equally effective, then oral ibuprofen for PDA closure would have several important advantages over the intravenous route. This study was d...

BACKGROUND Topical ibuprofen provides an alternative treatment to oral ibuprofen for the treatment of chronic knee pain. OBJECTIVE To compare the efficacy of topical versus oral ibuprofen in chronic knee pain treatment. STUDY DESIGN Prospective, randomized, unblinded pilot study. SETTING A private pain management practice. METHODS Twenty patients received either ibuprofen tablets 3 time...

Alzheimer's disease may result from low-grade inflammation of the brain, and the characteristic amyloid β may be a protective response. Epidemiological observation indicates that long-term oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen to patients having rheumatoid arthritis results in reduced risk and delayed onset of Alzheimer's disease. However, oral i...

BACKGROUND Adenotonsillectomy is one of the most common surgical procedures in children. Several complications and morbidities are common after nasal surgeries and the most common is pain. Several techniques have been employed to reduce the severity of postoperative pain. One of the preoperative techniques is pre-emptive analgesia through preventive central hypersensitization. This technique is...