When delivered to the oral mucosa, a variety of naturally occurring chemicals such as capsaicin from red chili peppers, piperine from black pepper, and nicotine from tobacco, cause a diffuse burning sensation often referred to as irritation. The burning sensation evoked by capsaicin increases when delivered repeatedly at 1 min intervals (sensitization), but then decreases markedly following a 1...

thereby representing a novel time course for desensitization. Our starting dose was higher than the 0.02-mg starting dose administered to a non-HIV patient during fluconazole desensitization; however, our initial dose was equal to or less than other protocols involving HIV-infected patients.1,5,6 Given this patient’s HIV status, we used a cautious desensitization approach (eg, dose escalation e...

Aspirin sensitivity is relatively frequent and can be a major problem in patients who need percutaneous coronary intervention and stenting with subsequent dual antiplatelet therapy. Desensitization is often the therapy in these patients, but this can prolong the time to revascularization significantly. Rapid oral aspirin desensitization protocols have been described since 2000. However, data ar...

Background & Aims: Allergic reaction is a common side effect of Efavirenz and drug replacement may not be an option to physicians. Here, a successful drug desensitization experiment on an 8-year-old female child over a period of 9 days is reported. Case presentation: The patient was an 8-year old female child with HIV in Kerman, Iran who had been received oral efavirenz together with lamivudine...

The oral desensitization using hypoallergenic wheat was performed for twenty children with a history of wheat allergy. The enrolled subjects were divided into three groups: children with severe wheat allergy, group S; children with mild wheat allergy, group M; children receiving no desensitization, group C. The oral desensitization was performed with increasing doses starting at 25 mg (group S)...

Capsaicin is a naturally occurring vanilloid that causes a hot, pungent sensation in the human oral cavity. This trigeminal stimulus activates TRPV1 receptors and stimulates an influx of cations into sensory cells. TRPV1 receptors function as homotetramers that also respond to heat, proinflammatory substances, lipoxygenase products, resiniferatoxin, endocannabinoids, protons, and peptide toxins...

BACKGROUND Patients with aspirin-sensitive rhinosinusitis, which is frequently associated with intrinsic bronchial asthma, can be desensitized by long-term treatment with oral aspirin. The exact mechanisms of this desensitization remain obscure, but modulations of the eicosanoid pathway occur and can be monitored with the help of a practicable in vitro assay on mixed leukocyte cultures. OBJEC...

A two year, 10 month-old child was referred to a tertiary allergy clinic following an adverse reaction to rifampin. Her mother had isoniazid-resistant pulmonary tuberculosis. The child was born in Canada, was asymptomatic, had a normal chest x-ray and liver enzymes. Mantoux induration was 17 mm. The child was prescribed oral rifampin, 150 mg per day for 3 months. Thirty minutes after ingesting ...

Allergies to iron salts are seldom reported. We studied a patient with iron-defi ciency anemia who had suffered anaphylactic reactions caused by oral iron salts. An allergy study was performed using single-blind, placebo-controlled oral challenge and skin tests with various iron salts as well as excipients in commercial formulations. Oral challenges were positive for 2 of the commercial formula...