OBJECTIVE To carry out a Failure Mode and Effects Analysis (FMEA) to the use of oral syringes. METHODS A multidisciplinary team was assembled within the Safety Committee.  The stages of oral administration process of liquid  medication were analysed, identifying the most critical and establishing the  potential modes of failure that can cause errors. The impact associated with  each mode of f...

BACKGROUND Melatonin is traditionally administered orally but has a poor and variable bioavailability. This study aims to present an overview of studies investigating the pharmacokinetics of alternative administration routes of melatonin. METHODS A systematic literature search was performed and included experimental or clinical studies, investigating pharmacokinetics of alternative administra...

Zinc oxide (ZnO) nanoparticles have received growing attention for several biomedical applications. Nanoparticles proposed for these applications possess the potential to interact with biological components such as the blood, cells/ tissues following their administration into the body. Hence we carried out in vivo investigations in Swiss Albino Mice to understand the interaction of ZnO nanorods...

the aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. the plasma concentrations of the four flavonoids were determined ...

in this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. eighty male wistar rats were divided into two series (n = 8 in each group). in the first series, all groups (except the control (con) group) ...

High standards of care are desirable for patients in any setting who receive chemotherapy by any route. Patients who self-administer oral chemotherapy are subject to risks of adverse effects similar to those who receive i.v. chemotherapy. Safeguards to prevent medication error in these patients may not be achieved to the same degree as for patients receiving i.v. drugs in an institutional setti...

The oral route of drug administration is generally preferred because of its versatility, safety and relative patient comfort. Liposomes have received much attention for their usefulness in reducing toxicity and improving therapeutic effectiveness. Although liposomes are a most promising, broadly applicable, and highly researched novel delivery system, they suffer from serious stability problems...

Zinc oxide (ZnO) nanoparticles have received growing attention for several biomedical applications. Nanoparticles proposed for these applications possess the potential to interact with biological components such as the blood, cells/ tissues following their administration into the body. Hence we carried out in vivo investigations in Swiss Albino Mice to understand the interaction of ZnO nanorods...