Structural damage in glaucoma often occurs before detectable loss in visual function.1-3 Accurate assessment of the optic disk and retinal nerve fiber layer (RNFL) morphology, however, is not always an easy task. Optical coherence tomograph (OCT), confocal scanning laser ophthalmoscope (CSLO) and scanning laser polarimeter (SLP) are the 3 commonly used imaging instruments for objective measurem...

Monitoring the shape changes of the optic disk is crucial for the early detection of glaucoma. This requires the optic disk to be segmented from the surrounding fundus. Previous methods required the boundary to be identified manually, for example, by specifying four control points on the boundary. This is not practical for routine clinical analysis, intra-observer and inter-observer variations ...

A micro-oxygen sensor was used to monitor the optic-disk oxygen tension in vivo in the cat. The perfusion pressure of the eye, defined as the systemic arterial blood pressure minus the intraocular pressure, was decreased. This was accomplished both by lowering the systemic arterial blood pressure by increasing the expiratory resistance and by elevating the intraocular pressure. The result of lo...

Visual receptive fields (RFs) were mapped inside and outside the cortical representation of the optic disk in the striate cortex (area V1) of anesthetized and paralyzed Cebus monkeys. Unexpectedly, most cells were found to be binocularly driven, and the RFs mapped with contralateral-eye stimulation progressed in a topographically appropriate fashion as the optic disk sector was crossed. Activat...

Young axons of new retinal ganglion cells (RGCs) in the continuously growing goldfish retina fasciculate with one another and their immediate forerunners on their path toward the optic disk and along the optic nerve. They express the immunoglobulin superfamily cell adhesion molecules (CAMs) neurolin (DM-GRASP) and the L1-like E587 antigen. Repeated injections of Fab fragments from polyclonal an...

A micro-oxygen sensor was used to monitor the optic-disk oxygen tension in vivo in the cat. The perfusion pressure of the eye, defined as the systemic arterial blood pressure minus the intraocular pressure, was decreased. This was accomplished both by lowering the systemic arterial blood pressure by increasing the expiratory resistance and by elevating the intraocular pressure. The result of lo...

OBJECTIVE To compare the morphology of normal, healthy Gottingen minipig retinal vessels of the optic disk with experimentally induced glaucomatous optic disks in order to identify the glaucomatous excavation. Present results were compared to human glaucoma findings. PROCEDURE Sixteen eyes from eight Göttingen minipigs were studied using fundoscopic photography and fluorescein angiography. Ex...