Tyrosine aminotransferase (TyrAT) catalyzes the transamination of L-Tyr and α-ketoglutarate, yielding 4-hydroxyphenylpyruvic acid and L-glutamate. The decarboxylation product of 4-hydroxyphenylpyruvic acid, 4-hydroxyphenylacetaldehyde, is a precursor to a large and diverse group of natural products known collectively as benzylisoquinoline alkaloids (BIAs). We have isolated and characterized a T...

Since the 19th century, opium has been produced and consumed in the areas of Asia, currently referred to as the Golden Crescent and the Golden Triangle (1). The Golden Crescent lies in South and Southwest Asia, including districts in the Northwest Frontier Province of Pakistan, the adjacent Badakhshan area of Afghanistan and the Baluchistan area of Iran. The area has been the scene of tradition...

Opium poppy (Papaver somniferum L.) has two major products: alkaloids in the capsules and the seeds.  The seed contains oil, protein, carbohydrate, moisture and mineral matters. The seed oil is rich in unsaturated fatty acids, particularly linoleic and oleic acid. Remaining meals after oil extraction are the important source for animal diets. The United Nations recognize Turkey and India as tra...

Opium poppy (Papaver somniferum L.) produces a large variety of isoquinoline alkaloids. The aim of this investigation is to understand the regulation of biosynthesis and the ecological function of the alkaloids in the plant. Agrobacterium-mediated transformations of opium poppy were used to introduce the berberine bridge enzyme cDNA bbe 1 in the antisense orientation into seedling explants. Aft...

Benzylisoquinoline alkaloids are a diverse class of plant specialized metabolites that includes the analgesic morphine, the antimicrobials sanguinarine and berberine, and the vasodilator papaverine. The two-electron oxidation of dihydrosanguinarine catalyzed by dihydrobenzophenanthridine oxidase (DBOX) is the final step in sanguinarine biosynthesis. The formation of the fully conjugated ring sy...

INTRODUCTION The term narcotic has had wide and inconsistent usage in lay, legal and scientific circles. Some use the word to characterize any drug which produces stupor, insensibility or sleep; many apply it only to derivatives of the opium plant ( `opiates'); others consider the term equivalent to 'addiction-producing'; and in legal matters, 'narcotics' may refer to almost any allegedly dange...

Ancient Egyptian and Greek pharmacopoeias reveal frequent use of different drugs, somniferous or narcotic, which contain poisonous elements. Among the toxic plants enumerated by Dioscorides, we find poppy and others. Egyptians were fond of taking these narcotic or euphoric substances attributed to nepenthes, but it is difficult to prove whether ancient people were aware of modern aspects of add...

Opium (powdered poppy Capsules) mixed with sugars and other plant products is a popular home made remedy for colic, cough and tonics for infants and children in Baluchistan. Over a period of 7 years (1977.1983) 28 children between the ages of I month to 5 years were admitted in Civil Hospital Quetta due to opium poisoning accounting for 0.16% of all paediatric admissions during the same period....

We model the economic incentives surrounding opium crop production in Afghanistan. Specifically, we examine the impact of eradication policies when opium is used as a means of obtaining credit, and when the crops are produced in sharecropping arrangements. The analysis suggests that when perfect credit markets are available, an increased risk of eradication will lead to less land being allocate...