INTRODUCTION Up to one in five people may have generalised anxiety disorder (GAD) at some point, and most have other health problems. Less than half of people have full remission after 5 years. GAD may have a genetic component, and has also been linked to previous psychological or other trauma. METHODS AND OBJECTIVES We conducted a systematic review and aimed to answer the following clinical ...

A 16-year-old boy in a coma (Glasgow scale 3) with general seizures was admitted to the intensive care unit. No palpable pulse necessitated cardiac massage. A blood specimen submitted to this laboratory tested positive for tricyclic antidepressants (TCA) by EMIT (Behring, Cupertino, CA) and negative by FPIA (Abbott, Wiesbaden, Germany). A number of antidepressants were screened for in blood by ...

Opipramol 2-HCl (OP) is used for therapy of general somatoform and anxiety disorders. Conventional tablets in the market contain 50 mg OP to be used once or up to three times a day in effective treatment of depression in mild. In case of serious depressive disorders, OP may be administired up to 300 mg a day. Decrease in frequency of high dose administration via sustained drug release would red...

•Morphological profiling can identify bioactive compounds and suggest putative targets•Thermal proteome of small molecules usually identifies multiple targets•Targets be prioritized by combining morphological thermal profiling•Thereby, a σ1 receptor antagonist was discovered Phenotypic screening for is typically combined with affinity-based chemical proteomics to uncover the respective molecula...