نتایج جستجو برای: opioid addiction

تعداد نتایج: 52416  

Journal: :Anesthesiology 2014
Kelly Yan Chen Lucy Chen Jianren Mao

Buprenorphine-naloxone (bup/nal in 4:1 ratio; Suboxone; Reckitt Benckiser Pharmaceuticals Incorporation, Richmond, VA) is approved by the Food and Drug Administration for outpatient office-based addiction treatment. In the past few years, bup/nal has been increasingly prescribed off-label for chronic pain management. The current data suggest that bup/nal may provide pain relief in patients with...

Journal: :Pain physician 2003

The (name of board) recognizes that the prevalence of addiction to heroin and other opioids has risen sharply in the United States and that the residents of the State of (name of state) should have access to modern, appropriate and effective addiction treatment. The appropriate application of up-to-date knowledge and treatment modalities can successfully treat patients who suffer from opioid ad...

Journal: :The American journal of medicine 2014
Sarah E Wakeman Traci C Green Josiah D Rich

In recent years, we have seen a rising tide of deaths documented in Centers for Disease Control and Prevention reports that bears a chilling familiarity to the early years of the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) epidemic. These deaths are from opioid overdoses, due to the underlying disease of opioid addiction, just as AIDS deaths are due to the under...

2017
Wade Berrettini

Increased physician prescribing of opioids to treat chronic nonprogressive pain has been accompanied by an increase in opioid addiction. Twin studies of opioid addiction are consistent with an inherited component of risk, approximately 50%. Several genome-wide association study (GWAS) reports indicate that genetic risk for opioid addiction is conveyed by many alleles of small effect (odds ratio...

2017
Jinghe Zhang Vijay Iyengar Bhanukiran Vinzamuri Hamsa S. Bastani Alexander R. Macalalad Anne E. Fischer Aleksandra Mojsilovic Kush R. Varshney

Addiction to opioid medications has become an epidemic affecting millions of Americans; drug overdoses accounted for more deaths than car crashes or gun violence in 2015. Oftentimes, the addiction begins when patients continue to take opioids for pain management beyond the required need. To combat the epidemic, it is vital to understand the exact circumstances under which medically-sanctioned t...

Journal: :Annals of clinical and laboratory science 2017
Keri Donaldson Laurence Demers Kirk Taylor Joe Lopez Sherman Chang

Over 116 million people worldwide have chronic pain and prescription dependence. In the US, opioids account for the majority of overdose deaths, and in 2014, almost 2 million Americans abused or were dependent on prescription opioids. Genetic factors may play a key role in opioid prescription addiction. Herein, we describe genetic variations between opioid addicted and non-addicted populations ...

2017
Amber Cragg Jeffrey P Hau Stephanie A Woo Christine Liu Mary M Doyle-Waters Corinne M Hohl

BACKGROUND Opioid addiction prevention has become an urgent public health priority, with several countries declaring a state of emergency due to rising death tolls from opioid abuse. Reducing the risk of developing addiction among opioid-naïve patients exposed to prescribed opioids during the process of medical care may be an important primary prevention strategy. Our objective is to synthesize...

2013
Beate Beer Robert Erb Marion Pavlic Hanno Ulmer Salvatore Giacomuzzi Yvonne Riemer Herbert Oberacher

It is becoming increasingly evident that genetic variants contribute to the development of opioid addiction. An elucidation of these genetic factors is crucial for a better understanding of this chronic disease and may help to develop novel therapeutic strategies. In recent years, several candidate genes were implicated in opioid dependence. However, most study findings have not been replicated...

2015
Nasim Vousooghi Mitra-Sadat Sadat Shirazi Ali Goodarzi Peyman Hassani Abharian Mohammad-Reza Zarrindast

INTRODUCTION X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. METHODS 30 adult females meeting DSM IV ...

Journal: :Australian Prescriber 2013

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