OBJECTIVE To investigate the effect of opiate substitution treatment at the beginning and end of treatment and according to duration of treatment. DESIGN Prospective cohort study. Setting UK General Practice Research Database. PARTICIPANTS Primary care patients with a diagnosis of substance misuse prescribed methadone or buprenorphine during 1990-2005. 5577 patients with 267 003 prescriptio...

Hydrotalcites have many important applications in catalysis, wastewater treatment, gene delivery and polymer stabilization, all depending on preparation history and treatment scenarios. In catalysis and polymer stabilization, thermal decomposition is of great importance. Hydrotalcites form easily with atmospheric carbon dioxide and often interfere with the study of other anion containing system...

OBJECTIVES To examine survival and long term cessation of injecting in a cohort of drug users and to assess the influence of opiate substitution treatment on these outcomes. DESIGN Prospective open cohort study. SETTING A single primary care facility in Edinburgh. PARTICIPANTS 794 patients with a history of injecting drug use presenting between 1980 and 2007; 655 (82%) were followed up by...

In a recent article, Lund et al sought to compare maternal and neonatal outcomes of various treatment regimens for opioid dependence during pregnancy.1 In their background, discussion the authors state that "In the United States buprenorphine plus naloxone [Suboxone(®)] … has been the preferred form of prescribed buprenorphine due to its reduced abuse liability relative to buprenorphine alone [...

OBJECTIVE To document the development of unique opioid-dependence treatment in remote communities that combines First Nations healing strategies and substitution therapy with buprenorphine-naloxone. DESIGN Quantitative measurements of community wellness and response to community-based opioid-dependence treatment. SETTING Remote First Nations community in northwestern Ontario. PARTICIPANTS...

Pakistan is among four countries in Asia where the estimated number of new HIV infections has been increasing year by year ever since 1990. The Asian Epidemic Modelling (AEM), conducted in 2015, reconfirmed that the use of contaminated injection equipment among people who inject drugs (PWID) remains the main mode of HIV transmission in the country. The estimated number of PWID ranges from 104,8...

Background & Aims: In this study the efficacy of traditional method, methadone tapering method and rapid method as three opiate detoxification treatments was compared based on demographic features and naltrexone consumption in a 6- month follow up. Method: This Cohort prospective study was performed on 140 opioid addict men referred to opiate detoxification center of Shahid Beheshti Hospital, K...

AIM To present medically assisted treatment for opiate addiction with substitution medicament Suboxone and prevention of social exclusion of young opiate addicts in Bosnia and Herzegovina. GENERAL OVERVIEW Until recently there was no solution for long-term and comprehensive treatment of young persons who suffer from opiate addiction. This is not an illness that impairs only psychological and ...

INTRODUCTION Despite research demonstrating the safety and benefit of breastfeeding in opioid substitution therapy, few women in treatment breastfeed. Understanding the factors contributing to the choices women on opioid substitution therapy make about infant feeding is important. OBJECTIVES The aim of this study was to better understand and support infant feeding choices and breastfeeding ex...

In this study, we examine the composition of electroencephalographic (EEG) oscillations within a broad frequency band (0.5-30 Hz) for opioid abuse (22 patients), during withdrawal (13 patients), and after 6 months of methadone treatment (6 patients) and in 14 healthy subjects during a resting condition (closed eyes). The exact compositions of EEG oscillations and their temporal behaviour were a...