OBJECTIVE To investigate opinions on the acceptable number of donation offspring in a national cohort of oocyte and sperm donors. DESIGN A prospective follow-up study on a national cohort of gamete donors. SETTING Sweden. METHODS Study-specific questionnaire. MAIN OUTCOME MEASURES Opinion on the acceptable number of offspring from one donor. RESULTS About half of both oocyte and sperm...

Objective The objective of this study was to evaluate LH/FSH and demographic variables on maturation stage of oocytes in patients with polycystic ovary syndrome (PCOS) with or without insulin resistance. MaterialsAndMethods Sixty patients with IVF/ICSI indication were subdivided into 3 groups as follow: 20 subjects were assigned to control (fertile women with male infertility history) group, 20...

Background: The biochemical characteristics of the follicular fluid (FF) play essential role in oocyte quality, the subsequent fertilization potential and embryo development. The oocyte quality and metabolism largely depends on follicular microenvironment. Present study aimed to investigate the relationship between oocyte quality and FF homocysteine (Hcy) level in women undergoing to IVF treatm...

Background: Process of oocyte freezing, seriously damages the molecular structure of the oocyte into the life and impair its ability to develop. It seems Oocytes can partially recompense those damages. The pentose phosphate pathway (PPP) constitutes the major source of NADPH required for the neutralization of reactive oxygen species (ROS). Glucose-6-phosphate dehydrogenase (G6PDH) is the first ...

BACKGROUND The intracytoplasmic sperm injection procedure ending with total fertilization failure is very distressfull event for both the clinician and the patient. OBJECTIVE The aim of this study was to identify independent factors which could be used to identify total fertilization failure before the day of intracytoplasmic sperm injection. MATERIALS AND METHODS This was a retrospective s...

Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular microenvironment and maternal signals, mediated primarily through granulosa cells (GCs) and cumulus cells (CCs), are responsible for nurturing oocyte growth, development and the gradual acquisition of oocyte devel...

Transcription factors in the germline play important roles in ovary formation and folliculogenesis, and control both oocyte development and somatic cell function. Factor in the germline (Figla) and newborn ovary homeobox gene (Nobox) represent a growing number of oocyte-specific transcription factors that regulate genes unique to oocytes. Studies on oocyte-specific transcription factors are imp...

the success of oocyte donation is influenced by multiple factors. we performed a retrospective analysis to evaluate prognostic factors in oocyte donation cycles. the main outcome measurements including recipient age, donor age, estradiol level in midcycle, the day of transfer and number of transferred embryos were not different in pregnant and non pregnant groups. endometrial pattern but not en...

Oocyte cryopreservation has great promise for applications in oocyte donation and fertility preservation and for decreasing the number of unused cryopreserved embryos. The Practice Committee has and will continue to review the published medical literature relating to oocyte cryopreservation at regular intervals and is prepared to reconsider its position when evidence warrants.

Background: Cryobiology and in vitro maturation of oocytes are very important tools of reproductive technology. Oocyte plays an important role in fertility. The objective of this research is comparison study the effect of invitro maturation and IVF fertilization of cryopreserved oocyte with fresh oocyte in mice. Materials and Methods: For this purpose, after superovulation was performed oocytes...