Os mecanismos reguladores do ciclo celular e sua inter-relação com fatores de crescimento, oncogenes anti-oncogenes têm se constituído nas áreas maior avanço no estudo da biologia câncer. Continuamente estão sendo descobertas novas proteínas envolvidas complexo mecanismo que desencadeia as diferentes fases celular, como também os seus ativação. A descoberta dessas co-fatores regulam transições ...

Abstract Currently, a significant increase in the levels of circulating cell-free DNA (cfDNA) blood patients is considered as generally recognized marker development oncological diseases. Although tumor-associated cfDNA has been well studied, its biological functions remain unclear. In this work, we investigated effect isolated from serum mice with B16-F10 metastatic melanoma on properties cell...

Autophagy is a self-protection mechanism of the body, and also an important physiological process for cells to maintain internal environment stability. Studies have shown that degree autophagy damage positively correlated with expression oncogenes, oncogenes closely related cervical HPV infection, so control ability can interfere virus infection. Traditional Chinese medicine believes dampness-h...

Genomic and functional alterations of enzymatic activity drive cancer metabolic reprogramming along with mutations tumor suppressors oncogenes [...]

Koalas suffer unusually high rates of neoplasia. There has been a long-standing correlation between koalas with the koala retrovirus (KoRV) and development neoplasia which lacked mechanistic explanation. We describe recent results that demonstrate many KoRV integrations lead to by (I) inserting into somatic cells preferentially near oncogenes, (II) germ oncogenes predisposing cancer, (III) tran...