نتایج جستجو برای: onchocerca volvulus
تعداد نتایج: 3233 فیلتر نتایج به سال:
On July 21 of 1975, an agreement was signed to start a collaboration project for the research of onchocerciasis. For this project, Japan decided to send researchers to Guatemala to aid Guatemalan staff of technicians in a research to combat a disastrous filariasis. This disease was discovered in this country by Dr. Rodolfo Robles in the year 1915 and that is why it is known as Robles disease. T...
BACKGROUND Onchocerciasis is endemic in the Imo River Basin, Nigeria. This study was aimed at assessing the prevalence and intensity of microfilaria of Onchocerca volvulus in the area. METHODS A cross-sectional study was carried out in the Okigwe Local Government Area, Imo State, Nigeria. Two skin snips (one from the waist and another from the shoulder) were taken from 1024 individuals examin...
Ivermectin is a safe, effective microfilaricide and microfilarial suppressant for Onchocerca volvulus; but in single doses of 100-200 micrograms/kg body weight it has no macrofilaricidal action. The present trial aimed to determine whether 6 doses of 100 micrograms/kg ivermectin, given at 2-week intervals, would kill the adult worms. Eighty-two nodules from 28 otherwise healthy adult male Liber...
The effect of increasing concentrations of ivermectin on adenosine triphosphatase (ATPase) activity was investigated in adult worms of Onchocerca volvulus. Mean Mg- and Na,K-ATPase activities decreased significantly (F ratio = 29.82, P < 0.01 and F ratio = 28.54, P < 0.01, respectively) with increasing concentrations of ivermectin (0-100 ng/ml) in the female worms. When male and female worms we...
Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, diethylcarbamazine (DEC), and albendazole are used in control programs for these diseases, but are mainly effective against the microfilarial stage and have minimal or no effect on adult worms. Adult Onchocerca volvulus an...
Infestation with organisms causing lymphatic filariasis (i.e. Wuchereria bancrofti and Brugia malayi) results in a variety of clinical presentations. It is possible that some of the variation is due to differences in host response to parasite. To determine whether individuals who live in an endemic area but differ in their clinical manifestations respond to different filarial antigens, we scree...
To evaluate the impact of onchocerciasis control programmes on the annual transmission potential, it is customary to monitor the man-biting rate of vector Siniuliuin (Diptera: Simuliidae) and the number of Oizclzocerca (Nematoda: Onchocercidae) infective larvae found in them (Walsh et al., 1978). In addition to the transmission of Onchocerca volvulus (Leuckart) causing human onchocerciasis, Sim...
Aspartic proteases are a relatively small group of enzymes which express in various nematodes including Onchocerca volvulus. An estimation of the gene copy number corresponding to the OV7A clone, which contains a cDNA insert encoding approximately two-thirds of the entire coding sequence of aspartic protease of O. volvulus, was made by slot blot analysis in a closely related species O. gibsonig...
The isolation of recombinant cDNA clones expressing antigens found in Onchocerca volvulus infective larvae is described. To isolate such clones, an expression cDNA library constructed from adult 0. volvulus RNA was screened with antiserum raised against infective larvae. One clone, designated XRAL-1 was characterized further. The recombinant antigen produced by XRAL-1 stimulates proliferation o...
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