CONTEXT Osteopathic physicians have used osteopathic manipulative medicine (OMM) to treat patients with acute otitis media (AOM) and its sequelae (eg, middle ear effusion [MEE], conductive hearing loss) for more than a century. However, few clinical trials document the efficacy of OMM, perhaps because of various challenges related to OMM clinical trials. OBJECTIVES To describe a research prot...

BACKGROUND In dental implant treatment, the long-term prognosis is dependent on the biologic seal formed by the soft tissue around the implant. The in vitro investigation of the implant-soft tissue interface is usually carried out using a monolayer cell-culture model that lacks a polarized-cell phenotype. This study developed a tissue-engineered three-dimensional oral mucosal model (3D OMM) to ...

CONTEXT Cranial osteopathic manipulative medicine (OMM) involves the manipulation of the primary respiratory mechanism to improve structure and function in children and adults. OBJECTIVE To identify and critically evaluate the literature regarding the clinical efficacy of cranial OMM. DATA SOURCES The clinical keywords "cranial manipulation" OR "osteopathy in the cranial field" OR "cranial ...

Dysfunction of PTEN-induced putative kinase 1 (PINK1), a Ser/Thr kinase with an N-terminal mitochondrial-targeting sequence (MTS), causes familial recessive parkinsonism. Reduction of the mitochondrial membrane potential limits MTS-mediated matrix import and promotes PINK1 accumulation on the outer mitochondrial membrane (OMM) of depolarized mitochondria. PINK1 then undergoes autophosphorylatio...

c-Kit mutations are frequently detected in mucosal melanomas, but their clinical significance in metastatic oral mucosal melanomas (OMM) remains unclear. The main purpose of this study was to investigate the clinical and pathological features of metastatic OMMs with c-Kit mutations and the efficiency of the tyrosine kinase inhibitor imatinib in treating metastatic OMMs. We found thatresidual pr...

We have isolated an outer mitochondrial membrane (OMM) fraction from baker's yeast. Saccharomyces cerevisiae, that possesses porin activity and contains a major polypeptide of 29,000 daltons. By analogy to similar data for an OMM fraction from rat liver and mung bean [Zalman, L. S., Nikaido, N. & Kagawa, Y. (1980) J. Biol. Chem. 255, 1771-1774], the 29,000-dalton polypeptide of the isolated yea...

Soghra Safaverdi, Gerard T. Barkema, 3 Eddy Kunnen, Adam M. Urbanowicz, and Christian Maes 1Instituut voor Theoretische Fysica, K.U.Leuven, Belgium 2Theoretical Physics, Utrecht, The Netherlands 3Instituut-Lorentz for Theoretical Physics, Leiden University, The Netherlands 4imec, Kapeldreef 75, 3001 Heverlee, Belgium 5Semiconductor Physics Section, Department of Physics and Astronomy, K.U.Leuve...

Oral mucosal melanoma (OMM) is a fatal sarcoma of unknown etiology. Histological morphology and genetic events are distinct from those of its cutaneous counterpart. Mutation and up-regulation of c-kit has been identified in OMM which may activate downstream molecules such as RAS and RAF. These molecules are involved in the mitogen-activated protein kinase (MAPK) pathway leading to tremendous ce...

The aim of the present study was to find the effects of pre and post vitrification taxol treatment on bovineimmature cumulus oocyte complexes (COCs). Bovine ovaries were collected from the local slaughterhousein a container with 30-37°C physiologic saline and supplemented with antibiotics. The grade A aspiratedCOCs were assigned to 6 experimental groups; The 1st group was control (n=100) in whi...

Role-based access control (RBAC) provides flexibility to security management over the traditional approach of using user and group identifiers. In RBAC, access privileges are given to roles rather than to individual users. Users acquire the corresponding permissions when playing different roles. Roles can be defined simply as a label, but such an approach lacks the support to allow users to aut...