Abnormal cellular metabolism is a hallmark of cancer, yet there is an absence of quantitative methods to dynamically image this powerful cellular function. Optical metabolic imaging (OMI) is a noninvasive, high-resolution, quantitative tool for monitoring cellular metabolism. OMI probes the fluorescence intensities and lifetimes of the autofluorescent metabolic coenzymes reduced NADH and flavin...

In this paper we report on the progress achieved within the framework of the joint ESA KNMI NIVR Calibration and Validation Announcement of Opportunity for the Ozone Monitoring Instrument aboard the NASA EOS Aura satellite. This OMI AO effort has rendered a wealth of validation results and scientific insights. Herein this contribution only a selection of the validation results is presented. OZO...

HtrA serine peptidase 2 (HtrA2), also named Omi, is a pro-apoptotic protein that exhibits dramatic changes in expression levels in a variety of disorders, including ischemia/reperfusion injury, cancer, and neurodegeneration. In our study, Omi/HtrA2 protein levels were high in the heart, brain, kidney and liver, with elevated heart/brain expression in aging mice. A similar expression pattern was...

Objective The purpose of this study was to investigate factors influencing the success rate of orthodontic microimplants (OMIs) using panoramic radiographs (PRs). Methods We examined 160 OMIs inserted bilaterally in the maxillary buccal alveolar bone between the second premolars and first molars of 80 patients (51 women, 29 men; mean age, 18.0 ± 6.1 years) undergoing treatment for malocclusio...

Near-to-real time as well as “archive quality” Brewer total ozone observations, which are performed with well maintained and calibrated instruments over the Northern Hemisphere have been used for the validation of the total ozone column product of the Ozone Monitoring Instrument (OMI) aboard the NASA EOS-Aura satellite. During the commissioning phase of OMI, the near-to-real time ground-based d...

(1) An important point is the large bias (30-50%) between OMI (KNMI DOMINO v2.0) and SCIAMACHY nadir (KNMI-BIRA TM4NO2A v2.3) retrievals, especially if both data sets are photochemically converted. It is puzzling me because Dirksen et al. (2011) and Hendrick et al. (2012) found a good agreement between OMI, SCIAMACHY nadir and groundbased observations, suggesting the absence of such a large bia...

Omi/HtrA2 is a mitochondrial proapoptotic serine protease that is able to induce both caspase-dependent and caspase-independent cell death. After apoptotic stimuli, Omi is released to the cytoplasm where it binds and cleaves inhibitor of apoptosis proteins. In this report, we investigated the role of Omi in renal cell death following cisplatin treatment. Using primary mouse proximal tubule cell...

Ozone Monitoring Instrument (OMI), launched in July 2004, is dedicated to the monitoring of the Earth’s ozone, air quality and climate. OMI is the successor of the Total Ozone Mapping Spectrometer (TOMS) instruments and provides among other atmospheric and radiometric quantities the total column of ozone (TOC), the surface ultraviolet (UV) irradiance at several wavelengths, the erythemal dose r...

Kidney fibrosis, a typical characteristic of chronic renal disease, is associated with tubular epithelial cell apoptosis. The results of our recent studies have shown that Omi/HtrA2 (Omi), a proapoptotic mitochondrial serine protease, performs a crucial function in renal tubular epithelial apoptotic cell death in animal models of acute kidney injury, including cisplatin toxicity and ischemia-re...

This paper presents our new formaldehyde (H2CO) retrievals, obtained from spectra recorded by the nadir instrument of the Ozone Mapping and Profiler Suite (OMPS) flown on board NASA’s Suomi National Polarorbiting Partnership (SUOMI-NPP) satellite. Our algorithm is similar to the one currently in place for the production of NASA’s Ozone Monitoring Instrument (OMI) operational H2CO product. We ar...