Lung cancer, especially non-small cell lung cancer (NSCLC), represents enormous challenges in continuously achieving treatment improvements. Besides cancer, obesity is becoming ever more prevalent. Obesity is increasingly acknowledged as a major risk factor for several types of common cancers. Significant mechanisms overlap in the pathobiology of obesity and tumorigenesis. One of these mechanis...

Atherogenesis is the narrowing of arteries due to plaque build-up that results in cardiovascular disease that can lead to death. The macrophage lectin-like oxidized LDL receptor-1 (LOX-1), also called the oxidized low-density lipoprotein receptor 1 (OLR1), is currently thought to aid in atherosclerotic disease progression; therefore metabolic studies have potential to both provide mechanistic v...

LOX-1, an OLR1 gene product, has been found to be the receptor for oxidized low density lipoprotein (LDL) to induce endothelial dysfunction. Animal studies suggested that LOX-1 promotes atherosclerosis, aggravates myocardial infarction, and enhances restenosis. Although researchers have mainly focused on coronary artery disease, reports on ischemic stroke are gradually accumulating. In parallel...

R ecently, two studies 2 reported independent evidence of genetic association between a 39 UTR single nucleotide polymorphism (SNP; rs1050283, also known as ‘‘+1073’’) in the oxidised LDL receptor 1 gene (OLR1) on chromosome 12p13.2 and risk for Alzheimer’s disease (AD). The implied chromosomal area is a highly promising AD candidate region because both genetic linkage and association studies h...

INTRODUCTION Myocardial infarction is caused by the obstruction of an artery in places of atherosclerosis plaque rupture. Endothelial cells during their activation express chemoattractant and adhesion molecules whereas infiltrating inflammatory cells produce enzymes, predisposing a lesion to rupture. MATERIAL AND METHODS We investigated the correlation between polymorphisms in the human genes...

BACKGROUND Natural selection shapes many human genes, including some related to complex diseases. Understanding how selection affects genes, especially pleiotropic ones, may be important in evaluating disease associations and the role played by environmental variation. This may be of particular interest for genes with antagonistic roles that cause divergent patterns of selection. The lectin-lik...

BACKGROUND Recently, the European Food Safety Authority approved a claim concerning the benefits of olive oil polyphenols for the protection of LDL from oxidation. Polyphenols could exert health benefits not only by scavenging free radicals but also by modulating gene expression. OBJECTIVE We assessed whether olive oil polyphenols could modulate the human in vivo expressions of atherosclerosi...

Our laboratory recently identified several differentially expressed genes (DEG) through microarray analysis of the sciatic nerves of 24-week-old BKS db/db (diabetic) and db/+ (nondiabetic) mice. We noted prominent increases in lipid metabolism genes, consistent with another model, the high fat-fed C57BL6/J mouse, where we postulated that oxidized low-density lipoproteins (oxLDL) activate a rece...