Six nitrogen-, sulfur- and cyclopropane-containing derivatives of cholestanol were examined as inhibitors of growth and sterol biosynthesis in the trypanosomatid protozoan Crithidia fasciculata. The concentrations of inhibitors in the culture medium required for 50% inhibition of growth were 0.32 microM for 24-thia-5 alpha,20 xi-cholestan-3 beta-ol (2), 0.009 microM for 24-methyl-24-aza-5 alpha...

To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and myelination, we utilized transgenic mice in which microRNA processing was disrupted in OL precursor cells (OPCs) and OLs by targeted deletion of Dicer1. We found that inhibition of OPC-OL miRNA processing disrupts normal CNS myelination and that OPCs lacking mature miRNAs fail to differentiate normally i...

statement of problem: considering the importance of the occlusal plane orientation in complete denture prostheses, a study was conducted on the relationship between this plane with ala-tragus and camper’s lines in soft tissue among individuals with class iii malocclusion, in mashhad school of dentistry. purpose: the aim of the present study was to define the best soft tissue index by which the ...

The brucellae are α-Proteobacteria facultative intracellular parasites that cause an important zoonosis. These bacteria escape early detection by innate immunity, an ability associated to the absence of marked pathogen-associated molecular patterns in the cell envelope lipopolysaccharide, lipoproteins and flagellin. We show here that, in contrast to the outer membrane ornithine lipids (OL) of o...

the main purpose followed in this study was to evaluate the role of social capital on organizational learning (ol) of jihad-e-agriculture organization's staffs. the statistical population consisted of all staffs of jihad-e-agriculture organization in kurdistan province (n=150). applying census, a questionnaire was sent to all the members of the study from whom 124 members finally filled in...

Literature on organizational learning (OL) shows that even firms who self-perceive themselves to have appropriate structures still fail generate outcomes. In this article, we claim one of the neglected key factors explaining failures are defensive routines (ODRs). Drawing literature, our theoretical inference is high levels ODRs can negatively moderate relationship between and OL. To test moder...

OL-protocadherin (OL-pc) is a transmembrane protein belonging to the cadherin superfamily, which has been shown to accumulate at cell-cell contacts via its homophilic interaction, but its molecular roles remain elusive. In this study, we show that OL-pc bound Nck-associated protein 1 (Nap1), a protein that regulates WAVE-mediated actin assembly. In astrocytoma U251 cells not expressing OL-pc, N...

We cloned a novel protocadherin cDNA, which we named OL-protocadherin (OL-pc), from mouse brain cDNA libraries. Its cytoplasmic region showed no similarities to other protocadherins, indicating that it belongs to a novel subfamily of protocadherins. Experiments using transfectants showed that OL-pc is a homophilic cell-cell adhesion molecule. The molecular mass of OL-pc was 140 kDa in the brain...

Ontology Learning (OL) is the computational task of generating a knowledge base in the form of an ontology given an unstructured corpus whose content is in natural language (NL). Several works can be found in this area most of which are limited to statistical and lexico-syntactic pattern matching based techniques (Light-Weight OL). These techniques do not lead to very accurate learning mostly b...

Array-OL, developed by Thomson Marconi Sonar, is a programming language dedicated to signal processing. An Array-OL program specifies the dependencies between array elements produced and consumed by tasks. In particular, temporal dependencies may be specified by referencing elements that belong to an infinite dimension of an array. A basic compilation strategy of Array-OL on a workstation has b...