Barrett's oesophagus is a preneoplastic condition in which the squamous mucosa of the oesophagus is replaced by columnar epithelium. Epithelial cells of Barrett's oesophagus were isolated from resected oesophagus specimens by two methods not previously applied to the culture of Barrett's oesophagus cells. These techniques included trypsinisation of small fragments of mucosa, followed by plating...

Ten cases of combined corrosive and peptic strictures of the oesophagus have been described. The peptic stricture of the oesophagus occurred 20 to 50 years after the corrosive burn. The authors believe that the hiatal hernia was due to the contraction of the fibrotic wall of the oesophagus, and therefore they prefer to call it a traction hiatal hernia. The operation of choice in these cases is ...

A case of verrucous squamous cell carcinoma of the oesophagus treated with bleomycin is reported. Bleomycin brought prompt reduction of the tumour and relief of symptoms. There have been no previous reports on experience with anti-cancer agents for verrucous carcinoma of the oesophagus. Administration of bleomycin might be an effective treatment for verrucous carcinoma of the oesophagus.

Gastro-oesophageal reflux disease and its sequela, Barrett's oesophagus, are the major recognized risk factors for oesophageal adenocarcinoma, a tumour whose frequency has increased dramatically in Western countries over the past few decades. Barrett's oesophagus develops through the process of metaplasia in which one adult cell type replaces another. The metaplastic, intestinal-type cells of B...

EDITORIAL SYNOPSIS Chagas disease due to a trypanosome infection may lead to extensive destruction of ganglion cells in the peripheral autonomic system and may result in gross enlargement of the oesophagus, colon, and heart. From studies on nerve cell counts it is concluded that the number of ganglion cells in the oesophagus must be reduced to less than half to produce functional disturbances i...

Abstract Introduction Megaoesophagus, dilatation of the oesophagus, is a recognised late complication achalasia cardia, Chagas disease and, less commonly, dysmotility disorders. Megaoesophagus often presents with dysphagia, regurgitation food and chest pain. Here, we describe case patient presenting stridor secondary to chronic in absence dysphagia. Case Report An 85-year-old female presented E...

The normal mechanism of preventing the reflux of gastric contents into the oesophagus has been studied intensely, but no hypothesis is so easy to prove and understand that it has obtained universal acceptance (Allison, 1956; Barrett, 1954; Botha, Astley, and Carre, 1957; Marchand, 1955). Methods of prevention of reflux which has resulted in oesophageal pathology are therefore variable. Reflux i...