نتایج جستجو برای: nvp bez235

تعداد نتایج: 1391  

2011
Misu Lee Marily Theodoropoulou Jochen Graw Federico Roncaroli Maria Chiara Zatelli Natalia S. Pellegata

Constitutive activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling cascade occurs in a variety of human malignancies, where it sustains tumor cell proliferation and survival. Pharmacologic blockade of this pathway exerts antineoplastic activity by triggering apoptosis and/or cell-cycle arrest. Pituitary adenomas show activation of the PI3K/AKT/mTOR pathway, but only a fracti...

2014
Xiang Shan Ren Yasunori Sato Kenichi Harada Motoko Sasaki Shinichi Furubo Jing Yu Song Yasuni Nakanuma

The polycystic kidney (PCK) rat is an animal model of Caroli's disease as well as autosomal recessive polycystic kidney disease (ARPKD). The signaling pathways involving the mammalian target of rapamycin (mTOR) are aberrantly activated in ARPKD. This study investigated the effects of inhibitors for the cell signaling pathways including mTOR on cholangiocyte proliferation of the PCK rat. Culture...

Journal: :Cancer research 2008
Violeta Serra Ben Markman Maurizio Scaltriti Pieter J A Eichhorn Vanesa Valero Marta Guzman Maria Luisa Botero Elisabeth Llonch Francesco Atzori Serena Di Cosimo Michel Maira Carlos Garcia-Echeverria Josep Lluis Parra Joaquin Arribas José Baselga

Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the tumor suppressor phosphatase and tensin homologue deleted from chromosome 10 or activating mutations of p110-alpha. These hotspot mutations result in oncogenic activity of the enzyme and contribute to therapeutic resistance to the anti-HER2 antibody trastuzumab. The PI...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Carlos Rodrigo Gil del Alcazar Molly Catherine Hardebeck Bipasha Mukherjee Nozomi Tomimatsu Xiaohuan Gao Jingsheng Yan Xian-Jin Xie Robert Bachoo Li Li Amyn A Habib Sandeep Burma

PURPOSE Inhibitors of the DNA damage response (DDR) have great potential for radiosensitization of numerous cancers, including glioblastomas, which are extremely radio- and chemoresistant brain tumors. Currently, there are no DNA double-strand break (DSB) repair inhibitors that have been successful in treating glioblastoma. Our laboratory previously demonstrated that the dual phosphoinositide 3...

2012
Katharina Blatt Harald Herrmann Irina Mirkina Emir Hadzijusufovic Barbara Peter Sabine Strommer Gregor Hoermann Matthias Mayerhofer Konrad Hoetzenecker Walter Klepetko Viviane Ghanim Katharina Marth Thorsten Füreder Volker Wacheck Rudolf Valenta Peter Valent

The phosphoinositide 3-kinase (PI3-kinase) and the mammalian target of rapamycin (mTOR) are two major signaling molecules involved in growth and activation of mast cells (MC) and basophils (BA). We examined the effects of the dual PI3-kinase/mTOR blocker NVP-BEZ235 on growth of normal and neoplastic BA and MC as well as immunoglobulin E (IgE)-dependent cell activation. Growth of MC and BA were ...

Journal: :Science translational medicine 2012
Yvan H Chanthery W Clay Gustafson Melissa Itsara Anders Persson Christopher S Hackett Matt Grimmer Elise Charron Slava Yakovenko Grace Kim Katherine K Matthay William A Weiss

Neuroblastoma, a tumor of peripheral neural crest origin, numbers among the most common childhood cancers. Both amplification of the proto-oncogene MYCN and increased neoangiogenesis mark high-risk disease. Because angiogenesis is regulated by phosphatidylinositol 3-kinase (PI3K), we tested a clinical PI3K inhibitor, NVP-BEZ235, in MYCN-dependent neuroblastoma. NVP-BEZ235 decreased angiogenesis...

Journal: :Biocell 2022

In order to explore the role of forkhead box protein O1 (FoxO1) in lipid metabolism and cell proliferation, goose primary hepatocytes were isolated incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVP-BEZ235, then transfected FoxO1 interference plasmid. The related parameters proliferation measured. results firstly showed that increased intracellular TG lipids concentration (P < 0...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Misu Lee Tobias Wiedemann Claudia Gross Ines Leinhäuser Federico Roncaroli Rickmer Braren Natalia S Pellegata

PURPOSE Novel therapeutic approaches are needed to improve the postoperative management of residual nonfunctioning pituitary adenomas (NFPA), given their high relapse rate. Here, we evaluated the antitumor efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in the only available model of spontaneous NFPAs (MENX rats). EXPERIMENTAL DESIGN Organotypic cultures of rat primary NFPAs were incubate...

Journal: :Molecular cancer therapeutics 2016
Marie Chanal Pascale Chevallier Véronique Raverot Guillaume Fonteneau Kristin Lucia Jose Luis Monteserin Garcia Alexa Rachwan Emmanuel Jouanneau Jacqueline Trouillas Jérôme Honnorat Carole Auger Marily Theodoropoulou Gérald Raverot

Aggressive pituitary tumors are rare but difficult to manage, as there is no effective chemotherapy to restrict their growth and cause their shrinkage. Within these tumors, growth-promoting cascades, like the PI3K/mTOR pathway, appear to be activated. We tested the efficacy of two inhibitors of this pathway, NVP-BKM120 (Buparlisib; pan-PI3K) and NVP-BEZ235 (dual PI3K/mTOR), both in vitro on imm...

Journal: :Cancer research 2014
Aifu Lin Hai-Long Piao Li Zhuang Dos D Sarbassov Li Ma Boyi Gan

The PI3K-AKT pathway is hyperactivated in many human cancers, and several drugs to inhibit this pathway, including the PI3K/mTOR dual inhibitor NVP-BEZ235, are currently being tested in various preclinical and clinical trials. It has been shown that pharmacologic inhibition of the PI3K-AKT pathway results in feedback activation of other oncogenic signaling pathways, which likely will limit the ...

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