نتایج جستجو برای: numerical panel method npm
تعداد نتایج: 1929502 فیلتر نتایج به سال:
BRCA2 germline mutations account for the majority of heredity breast and ovarian cancer. Besides its role in DNA damage repair, BRCA2 also plays an important role in cytokinesis, transcription regulation, and cancer cell proliferation. Recently, we reported that BRCA2 localizes to centrosomes as well as nuclei and the dysfunction of BRCA2 in a centrosome causes abnormalities in cell division. H...
Nucleophosmin (NPM)/B23, a multifunctional nucleolar phosphoprotein, plays an important role in ribosome biogenesis, cell cycle regulation, apoptosis and cancer pathogenesis. The role of NPM in cells is determined by several factors, including total expression level, oligomerization or phosphorylation status, and subcellular localization. In the nucleolus, NPM participates in rRNA maturation to...
OBJECTIVE The aim of this study was to quantify the copies of circulating nucleophosmin (NPM) mutations DNA in the plasma of patients with acute myeloid leukemia (AML) and to explore the association of circulating NPM mutation levels with clinical characteristics. DESIGN AND METHODS The presence of NPM mutations in 100 Chinese patients newly diagnosed with AML were identified by RT-PCR and se...
Nucleophosmin (NPM) is an important phosphoprotein with pleiotropic functions in various cellular processes. Although phosphorylation has been postulated as an important functional determinant, possible regulatory roles of this modification on NPM are not fully characterized. Here, we find that NPM is dephosphorylated on various threonine residues (Thr199 and Thr234/237) in response to UV-induc...
The (2;5)(p23;q35) translocation which results in the fusion ofthe NPM (nucleophosmin) gene on chromosome 5q35 with the novelALK (anaplas tic lymphoma kinase) gene on chromosome 2p23 [S.W. Morris et aI, Science (Washington DC), 263: 1281-1284, 1994] is associated with lU-i (CD3O)-posltlve anaplastic large cell lymphomas (ALCL); a group of morphologicaHy and Immunophenotypically heterogenous hig...
The purpose of this study is to explain the Effect Liquidity, Leverage, and Profitability on Company Performance in Companies Listed Indonesia Stock Exchange 2018 - 2020. objects are Exchange, totaling 13 samples from population having financial statement data. By using panel data regression analysis method. sampling technique used purposive technique. results indicate that Current Ratio has a ...
This study aims to determine the effect of macroeconomic and company-spesific factors in determining stock price financial industry. The independent variables used are Inflation, Economic Growth Return on Asset (ROA), Net Profit Margin (NPM), dan Earning per Share (EPS). While dependent variable is price. Research data taken by purposive sampling method, wich means that with certain criteria. o...
In animal cells, duplication of centrosomes and DNA is coordinated. Since CDK2/cyclin E triggers initiation of both events, activation of CDK2/cyclin E is thought to link these two events. We identified nucleophosmin (NPM/B23) as a substrate of CDK2/cyclin E in centrosome duplication. NPM/B23 associates specifically with unduplicated centrosomes, and NPM/B23 dissociates from centrosomes by CDK2...
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