About 30 Bacillus isolates from various sources like shrimp intestine, pond water and pond sediment were assayed for susceptibility to 16 antibiotics, which included cell wall synthesis inhibitors, protein synthesis inhibitors and nucleic acid synthesis inhibitors. Most of the isolates were more sensitive against protein synthesis inhibitors than nucleic acid synthesis inhibitors. Present study...

Previous studies on purineless mutants of Aerobacter aerogenes have shown that a guanineless mutant, strain P-14, which accumulates xanthosine in its culture fluids, lacks the ability to produce nucleic acid guanine either by synthesis de novo or from adenine, but is capable of synthesizing nucleic acid adenine from small precursors (24). These results appeared to implicate a derivative of xant...

Medicinal plants exerted their antibacterial effects through many mechanisms included inhibition of cell wall synthesis, membrane disruption cytoplasmic membrane, bacterial proteins nucleic acid energy metabolism, as well virulence factors. The current review highlighted the medicinal with activity spectrum action.

Numerous reports have been published on the properties and reaction mechanism of the highly purified enzyme preparations that catalyze the deoxyribonucleic acid-directed synthesis of ribonucleic acid (l-6). The various RNA polymerases tudied, although differing in some respects, show a remarkable similarity in their cofactor requirements, reaction kinetics, physical properties, and facility to ...

We report the asymmetric synthesis of di-3-pentyl (3S,alphaS,7E)-3-N-benzyl-N-alpha-methylbenzylamino-dec-7-enedioate (9), which contains the correct functionalization to produce delta-amino acid derivatives to be used as monomers for Peptide Nucleic Acid (PNA) formation With this aim, thymine-pentanoic acid 15 and some of its ester derivatives were obtained, their reactivity was studied and th...

The chemical changes occurring during embryonic development have been studied by several workers (l-3). In the hen’s egg there is very little nucleic acid present, whereas a considerable synthesis of both desoxypentose nucleic acid (DNA) and ribose nucleic acid (RNA) occurs in the embryo (4-6). Recently, methods for the determination of purines and pyrimidines in small amounts of tissue have be...

INTRODUCTION Genetics, a subject with diverse aspects, is here treated from the nucleic acid chemist's point of view, since nucleic acid chemists have contributed and still can contribute a great deal to the problern of genetic information, genetic transcription, and regulation (Figure 1). Synthetic polynucleotides of known composition and known sequence in many cases allow definition of a prob...