Dramatic changes in cell and nuclear size occur during development and differentiation, and aberrant nuclear size is associated with many disease states. However, the mechanisms that regulate nuclear size are largely unknown. A robust system for investigating nuclear size is early Xenopus laevis development, during which reductions in nuclear size occur without changes in DNA content. To identi...

The dependence of the 6s−7s PNC amplitude in Cs on the radius of the neutron distribution is studied. It is found that differences in neutron and proton r.m.s. radii for Cs predicted in recent nuclear structure calculations lead to a 0.26% reduction in the 6s − 7s PNC amplitude; a factor of 3 greater than the change predicted in previous calculations.

A long-standing biological question is how a eukaryotic cell controls the size of its nucleus. We report here that in fission yeast, nuclear size is proportional to cell size over a 35-fold range, and use mutants to show that a 16-fold change in nuclear DNA content does not influence the relative size of the nucleus. Multi-nucleated cells with unevenly distributed nuclei reveal that nuclei surr...