Proteolytic resistance of Notch prior to ligand binding depends on the structural integrity of a negative regulatory region (NRR) of the receptor that immediately precedes the transmembrane segment. The NRR includes the 3 Lin12/Notch repeats and the juxtamembrane heterodimerization domain, the region of Notch1 most frequently mutated in T-cell acute lymphoblastic leukemia lymphoma (T-ALL). Here...

Non-radiative recombination (NRR) of excited carriers poses a serious challenge to optoelectronic device efficiency. Understanding the mechanism is thus crucial to defect physics and technological applications. Here, by using first-principles calculations, we propose a new NRR mechanism, where excited carriers recombine via a Frenkel-pair (FP) defect formation. While in the ground state the FP ...

21 Cognitive rehabilitation (CR) treatment consists of hierarchically organized tasks that require repetitive 22 use of impaired cognitive functions in a progressively more demanding sequence. Active monitoring of 23 the progress of the subjects is therefore required, and the difficulty of the tasks must be progressively 24 increased, always pushing the subjects to reach a goal just beyond what...

We have expanded the original Glucocorticoid Receptor Resource (GRR) database to include several individual resources as part of a larger project called the Nuclear Receptor Resource (NRR). In addition to the GRR, the NRR currently features the Thyroid Hormone Receptor Resource, the Androgen Receptor Resource, the Mineralocorticoid Receptor Resource, the Vitamin D Receptor Resource, and the Ste...

This review focusses on the fundamentals of NRR, factors influencing NRR kinetics and advent development transition metal-based catalysts such as borides, carbides nitrides due to their specific importance in reinforcing NRR.

Notch receptors are core components of the Notch signaling pathway and play a central role in cell fate decisions during development as well as tissue homeostasis. Upon ligand binding, Notch is sequentially cleaved at the S2 site by an ADAM protease and at the S3 site by the γ-secretase complex. Recent X-ray structures of the negative regulatory region (NRR) of the Notch receptor reveal an auto...

Consolidation, Combination and Diversification (CCD’s) in the emerging globalized market leads to competition and escalating the monopoly power. Given the increasing liberalization of rules, regulations and law, a number of firms are going beyond national borders and making deals triumphant. We suggest an innovative firm valuation model for M&A in the area of Corporate Finance that is NRR Appro...

The relevance of the neuroretinal ring (NRR) for early diagnostic of glaucoma is not a novel concept. In fact, we can all remember the ISNT mnemonic rule, which represented the distribution of sector thicknessess characteristic of a healthy NRR, for discriminating between normal papilla (rule intact) and suspect or glaucomatous papillae (rule infringed). This rule was not infallible because it ...

We address the issue of modeling and quantifying myocardial contraction from 4D MR sequences, and present an unsupervised approach for building and using a statistical 3D motion atlas for the normal heart. This approach relies on a state-of-the-art variational non rigid registration (NRR) technique using generalized information measures, which allows for robust intra-subject motion estimation a...

The objective of this study was to investigate whether variation in sperm motility, after preselection of bulls for this trait, has any impact on the non-return rate (NRR). The material consisted of pre- and post-freezing motility records and NRR records from 117 young Al bulls with at least 100 services each. Data representing 2 breeds at 2 different Al studs were analysed within studs. Both q...