Prostaglandins are a class of molecules that mediate cellular inflammatory responses and control cell growth. The oxidative conversion of arachidonic acid to prostaglandin H2 is carried out by two isozymes of cyclooxygenase, COX-1 and COX-2. COX-1 is constitutively expressed, while COX-2 can be transiently induced by external stimuli, such as pro-inflammatory cytokines. Interestingly, COX-2 is ...

The cyclooxygenase (COX) enzyme system is the major pathway catalyzing the conversion of arachidonic acid into prostaglandins (PGs). PGs are lipid mediators implicated in a variety of physiological and pathophysiological processes in the kidney, including renal hemodynamics, body water and sodium balance, and the inflammatory injury characteristic in multiple renal diseases. Since the beginning...

A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...

Abstract Background Alzheimer’s disease is currently one of our greatest socioeconomic challenges. Understanding the ability biomarkers to predict clinical progression, prior significant cognitive decline, critical when considering secondary prevention strategies. Here we consider association between a range single time‐point baseline in cognitively‐normal group and subsequent risk developing M...

Cyclooxygenase (COX) is the key enzyme within the complex conversion of arachidonic acid into prostaglandins (PGs). Inhibitors of this enzyme represent a particularly promising class of compounds for chemoprevention and cancer therapy. The experimental data on the involvement of COX isoform COX-2 in tumour development and progression, as well as the observed overexpression of COX-2 in a variety...

"> Long-chain alkanes are a major constituent of crude oils and their conversions into other compounds are of interest depending on the specific application. Here, five <span style="font-size: 9pt; color...

This paper presents an algorithm for voxel-based reconstruction of objects with general reflectance properties from multiple calibrated views. It is assumed that one or more reference objects with known geometry are imaged under the same lighting and camera conditions as the object being reconstructed. The unknown object is reconstructed using a radiance basis inferred from the reference object...