We introduce a nonparametric Bayesian model for a phase II clinical trial with patients presenting different subtypes of the disease under study. The objective is to estimate the success probability of an experimental therapy for each subtype. We consider the case when small sample sizes require extensive borrowing of information across subtypes, but the subtypes are not a priori exchangeable. ...

Methods are introduced and illustrated for synthesizing evidence from case-control and cohort studies and controlled trials, accounting for differences among the studies in their design, length of follow-up, and quality. The methods, based on hierarchical but nonexchangeable Bayesian models, are illustrated in a synthesis of disparate information about the health effects of passive exposure to ...

Influx of [3H]methotrexate into freshly isolated hepatocytes in suspension is mediated by two routes, one with a high affinity (Km = 5.9 microM) and another with a low affinity for methotrexate. Both transport routes are equally sensitive to the sulfhydryl group inhibitor, p-chloromercuriphenylsulfonic acid, alterations in temperature, substitution of extracellular Na+ with choline, and inhibit...

Corn (Zea mays L.) grown on sandy Atlantic Coastal Plain soils is often unresponsive to applications of K fertilizer. The purpose of this investigation was to examine the response of irrigated, intensively managed corn to K applications, and to monitor changes in soil K status. Field studies were conducted for 3 yr at four sites on the Delaware Coastal Plain. Treatments consisted of 0, 94, or 2...

We connect the empirical or ‘occupation’ laws of certain discrete space time-inhomogeneous Markov chains, related to simulated annealing, a novel class ‘stick-breaking’ processes, ‘nonexchangeable’ generalization Dirichlet process used in nonparametric Bayesian statistics. To make this unexpected correspondence, we examine an intermediate ‘clumped’ structure both chains and stick-breaking perha...