With increasing emphasis on expanding home-based dialysis, there is a need to understand adherence outcomes. This study set out to examine the prevalence and predictors of nonadherence among patients undergoing peritoneal dialysis. A cross sectional sample of 201 peritoneal dialysis patients recruited between 2010-2011 from Singapore General Hospital completed measures of quality of life, medic...

BACKGROUND Antipsychotic medication reduces the severity of serious mental illness (SMI) and improves patient outcomes only when medicines were taken as prescribed. Nonadherence to the treatment of SMI increases the risk of relapse and hospitalization and reduces the quality of life. It is necessary to understand the factors influencing nonadherence to medication in order to identify appropriat...

BACKGROUND End-stage kidney disease (ESKD) patients are often prescribed multiple medications. Together with a demanding weekly schedule of dialysis sessions, increased number of medicines and associated regimen complexity pre-dispose them at high risk of medication nonadherence. This review summarizes existing literature on nonadherence and identifies factors associated with nonadherence to me...

BACKGROUND Many patients experience difficulties in following treatment recommendations. This study's objective is to identify nonadherence risk profiles regarding medication (antidepressants, antihypertensives, and oral hypoglycemics) from a combination of patients' socio-demographic characteristics, morbidity presented within general practice and medication characteristics. An additional obje...

Accounting for subject nonadherence and eliminating inappropriate subjects in clinical trials are critical elements of a successful study. Nonadherence can increase variance, lower study power, and reduce the magnitude of treatment effects. Inappropriate subjects (including those who do not have the illness under study, fail to report exclusionary conditions, falsely report medication adherence...

conclusions levothyroxine absorption testing over 2 hours may offer a more rapid alternative to the commonly used longer protocols to rule out malabsorption. scheduling a levothyroxine absorption test may induce some patients to start adhering to levothyroxine therapy. patients and methods serum levels of thyroid stimulating hormone (tsh), ft4, and free triiodothyronine (ft3) were drawn at 0, 6...

BACKGROUND It is believed that nonadherence is the proximate cause of multidrug-resistant tuberculosis (MDR-tuberculosis) emergence. The level of nonadherence associated with emergence of MDR-tuberculosis is unknown. Performance of a randomized controlled trial in which some patients are randomized to nonadherence would be unethical; therefore, other study designs should be utilized. METHODS ...

OBJECTIVE To determine the association between prescription nonadherence and the health of older adults with 1 or more of 5 chronic conditions. STUDY DESIGN Analysis of the correlation between prescription nonadherence and the health of older adults. METHODS Data were from a 7-year panel with information on healthcare encounters and prescriptions. We used fixed-effects Cox duration regressi...

Estimates of nonadherence in patients over 65 years of age with chronic conditions vary from 40% to 75%. A study looking at hospitalizations in patients over the age of 65 found that 11% of admissions were related to nonadherence to medications. Interestingly, nonadherence in the elderly is often intentional. In a study of nonadherence and adverse drug reactions in elderly patients admitted to ...

BACKGROUND Medication nonadherence is widespread, but there are few efficient means of detecting medication nonadherence at the point of care. Visit-to-visit variability in clinical biomarkers has shown inconsistent efficiency to predict medication adherence. OBJECTIVE To examine the performance of visit-to-visit variability (VVV) of hemoglobin A1c to predict nonadherence to antidiabetic medi...