A series of bis(indolyl)methanes have been synthesized by stirring a mixture of indole and aldehydes in methanol:water (1:1 v/v) containing catalytic amount of sodium bisulphite at RT. Acute toxicity, analgesic, anti-inflammatory and ulcerogenic activities of the prepared bis(indolyl)methanes are evaluated in vivo in comparison to standard drugs (ibuprofen and indomethacin). In acute toxicity s...

In our study, a series of novel 3-(4-(benzylideneamino) phenylimino) 4-fluoroindolin-2-one derivatives were synthesized and characterized by spectral (I.R, (1)H NMR, mass) and elemental analysis. The title compounds (N(1)-N(10)) were evaluated for analgesic, anti-inflammatory, and ulcerogenic index activities. Results displayed that compound N(3) exhibited significant analgesic activity. Among ...

A new series of 5-substituted-3-methylsulfanyl-1-(2,4-dinitro phenyl)-1H-pyrazole-4-carboxylic acid ethyl esters were synthesized by reacting the amino group of 5-amino-3-methylsulfanyl-1-(2,4-dinitro phenyl)-1H-pyrazole-4carboxylic acid ethyl ester with acid anhydrides, acid chlorides and phenyl dithiocarbamates. The title compounds were investigated for analgesic, anti-inflammatory and ulcero...

Measurement of changes in buccal mucosal potential difference produced by contact with drug formulations may provide a means of predicting their mucosal toxicity and ulcerogenic activity.

A series of thiazolidin-4-one (2a–h; 3a–h), azetidin-2-one (4a–h) and 1,3,4-oxadiazole (5a–h) derivatives of isoninicotinic acid hydrazide (INH) were synthesized in order to obtain new compounds with potential anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities. The structures of the new compounds were supported by their IR, 1H-NMR and mass spectral data. All compounds w...

Non-steroidal Anti-inflammatory drugs (Aceclofenac, Mefenamic acid) have conjugated with different antioxidants such as Thymol, Menthol which having antiulcerogenic activity with the NSAIDsantioxidant mutual prodrug gastro sparing NSAIDs devoid of Ulcerogenic side effects. Two mutual Prodrugs have synthesized in which NSAIDs have been conjugated with different antioxidants by a glycolic acid sp...