Background: Previous studies have demonstrated that patients with insulin-dependent diabetes mellitus (IDDM) have a high prevalence of osteopenia.  Hypercalciuria has also been well documented in human diabetes and many children with insulin-dependent diabetes mellitus have short stature. Objective: To investigate the relationship of hypercalciuria and hyperphosphaturia with growth retardation ...

Understanding the management of non-insulin-dependent (type 2) diabetes (NIDDM) requires the grasp of three concepts. Firstly, the condition is steadily progressive and demands appropriate changes of therapy over time. Secondly, therapeutic aims must be set for three parameters: plasma lipids, plasma glucose and blood pressure. Thirdly, the condition is dangerous and regular screening for early...

OBJECTIVE We assessed the accuracy of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), developed from the Diabetes Prevention Trial-Type 1 (DPT-1), in the TrialNet Natural History Study (TNNHS). RESEARCH DESIGN AND METHODS Prediction accuracy of the DPTRS was assessed with receiver-operating characteristic curve areas. The type 1 diabetes cumulative incidence within the DPTRS interval...

Much of the public media discussion of genetics of common diseases has centered on opportunities for targeted preventive actions. At the same time, in the specialist literature, there has been extensive discussion of ‘‘interaction,’’ both between genes and between genes and environment. These two topics concern the use and interpretation of statistical models for risk of diseases with several, ...

BACKGROUND Successful management of diabetes requires attention to the behavioural, psychological and social aspects of this progressive condition. The Diabetes MILES (Management and Impact for Long-term Empowerment and Success) Study is an international collaborative. Diabetes MILES--Australia, the first Diabetes MILES initiative to be undertaken, was a national survey of adults living with ty...

Incidence of Type 1 Diabetes in Finland The incidence of type 1 diabetes (T1D), one of themost prevalent chronicdisease inchildren,has increasedworldwide.1The highest recorded incidence in children younger than 15 years was 64.2 per 100000person-years inFinland in 2005.2Weexamined the incidence rates between 2006 and 2011 in Finnish children younger than 15 years as well as the 32-year trend (1...

abstract diabetes mellitus is one of the major metabolic disorders. diabetes is recognized for severe complications including diabetic nephropathy, neuropathy and retinopathy. long-lasting effect of hyperglycemia results in increased oxidative stress. oxidative stress results from an imbalance between radical-generating and radical scavenging systems. increased oxidative stress has been shown t...

OBJECTIVES To examine the structure and psychometric properties of a general childrearing [Coparenting Questionnaire (CQ)] and an adapted Diabetes-Specific Coparenting Questionnaire (DCQ) and compare general and diabetes-specific coparenting among two-parent families caring for a child with type I diabetes. METHODS Mothers and fathers of children (N=61) aged 8-12 years with type I diabetes co...

Pregestational diabetes is a common medical complication of pregnancy and preconception planning is an essential component of care for affected women of childbearing age. Once pregnant, structured care in a multidisciplinary team setting is necessary to ensure optimal outcomes. Although significant progress has been made, these women and their offspring remain to have a significantly elevated r...