Our objective was to determine duodenal and ileal flows of total and esterified fatty acids and to determine ruminal fermentation characteristics and site and extent of nutrient digestion in sheep fed an 80% concentrate diet supplemented with high-linoleate (77%) safflower oil at 0, 3, 6, and 9% of DM. Oil was infused intraruminally along with an isonitrogenous basal diet (fed at 2% of BW) that...

Functionally hepatectomized rabbits showed convulsions and coma within 2 hours after the intravenous injection of fat emulsion and heparin. Intravenous injection of the detergent triton prevented this syndrome, if given before the fat emulsion and heparin, and reversed it if given subsequently. Extremely high plasma non-esterified fatty acid levels were noted in rabbits showing the convulsive s...

FoUR major classes of lipid are found in human serum: cholesterol and its esters, triglyceride, phospholipids and non-esterified fatty acids. They exist in aqueous solution because they are combined with protein to form lipoprotein complexes. The non-esterified fatty acids are bound to albumin, and the other lipids are associated with certain serum globulins. The nomenclature of the lipoprotein...

Three major regulatory steps can be recognized in the control of ketogenesis (Fig. 1): (1) regulation of the supply of the major ketogenic substrate, plasma non-esterified fatty acids, by control of their release from adipose tissue; (2) regulation in the liver of the relative fluxes of non-esterified fatty acids through the pathways of /3-oxidation and esterification; (3) regulation in the liv...

In the suckling newborn rat, blood ketone bodies begin to increase slowly 4h after birth and then rise sharply between 12 and 16h, whereas the major increase in plasma non-esterified fatty acids and liver carnitine occurs during the first 2h of life, parallel with the onset of suckling. In the starved newborn rat, which shows no increase in liver carnitine unless it is fed with a carnitine solu...

background: the modern dairy cows, due to intensive selection for higher milk production during past decades, have become more resistant to insulin. accompanied with dmi depression in per parturient dairy cow, insulin resistance may lead to a massive release of non-esterified fatty acids (nefa) to bloodstream which might act as a start point for development of other diseases. objectives: the pu...