Germline stem cell (GSC) self-renewal and differentiation into gametes is regulated by both intrinsic factors in the germ line as well as extrinsic factors from the surrounding somatic niche. dWnt4, in the escort cells of the adult somatic niche promotes GSC differentiation using the canonical β-catenin-dependent transcriptional pathway to regulate escort cell survival, adhesion to the germ lin...

Wnt signaling controls a wide range of developmental processes and its aberrant regulation can lead to disease. To better understand the regulation of this pathway, we identified zebrafish homologues of Naked Cuticle (Nkd), Nkd1 and Nkd2, which have previously been shown to inhibit canonical Wnt/beta-catenin signaling. Zebrafish nkd1 expression increases substantially after the mid-blastula tra...

Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and res...

in order to have a successful breeding program, it is important to determine the relationship among the traits. this study was conducted at research farm of isfahan university of technology to evaluate relationships among some of the agronomic and physiological traits and grain yield of ten bread wheat cultivars in optimum and stress moisture (irrigation after 70±3 and 130±3 mm evaporation from...

Non-canonical base pairs are planar hydrogen-bonded of nucleobases, having hydrogen bonding patterns which differ from the observed in Watson-Crick pairs, as classic double-helical DNA. The structures polynucleotide strands both DNA and RNA molecules can be understood terms sugar-phosphate backbones consisting phosphodiester-linked D 2’ deoxyribofuranose (D ribofuranose RNA) sugar moieties, wit...