abstract anti-nociceptive activity of aerial parts of phytolacca americana were investigated, using the hot plate method in mice. results of the present study showed that the aqueous methanolic extract of aerial parts of p. americana produced a statistically significant increase in pain threshold after 30 min, in comparison with the control, at adose of 190 mg kg-1 (p<0.001). the activity was c...

were compared in a small preliminary psychophysical study (N=6). A two minute cold pressor test was applied as nociceptive conditioning stimulus (e.g. [2]). Electrocutaneous stimulation [3] was used for nociceptive detection threshold tracking before, during and after the conditioning stimulus. The local ethics committee approved all experiment procedures and consent was obtained from all subje...

Background: Prostaglandins play a major role in inflammation and pain. They are synthesised by the two cyclooxygenase (COX) isoforms: COX-1, which is expressed constitutively in many cell types and COX-2, which is induced at the site of inflammation. However, unlike peripheral tissues, COX-2 is expressed constitutively in the central nervous system and may play a role in nociceptive processes. ...

Cannabinoids suppress nociceptive processing of acute stimuli, but little is known about their effects on processes that lead to hyperexcitability of nociceptive neurons following prolonged noxious stimulation. Wind-up, the increasingly strong response of spinal nociceptive neurons to repetitive noxious electrical stimuli, results from a fast-rising cumulative depolarization and increase in int...

BACKGROUND Prostaglandins play a major role in inflammation and pain. They are synthesized by the two cyclooxygenase (COX) isoforms: COX-1, which is expressed constitutively in many cell types, and COX-2, which is induced at the site of inflammation. However, unlike peripheral tissues, COX-2 is expressed constitutively in the central nervous system and may play a role in nociceptive processes. ...

Aim: The aim of this study was to verify the pain behavior to electroacupuncture (EACP) in rabbit tooth-pulp assay. Methods: Albino rabbits weighing 1.5-2.0 kg) were pretreated with saline or morphine (5mg/kg, e.v.) 10 min before the nociceptive test (NT). In another group, EACP (rectangular pulses, f1=2 Hz, f2=0.1 s, 3 mA) was applied in acupoints and sham points, before and during the NT. Aft...

Locations and response characteristics of nociceptive neurons in the dorsal horn of the spinal cord were studied in urethane-chloralose anesthetized Japanese macaques. There were two general categories of nociceptive neurons. Neurons of the first type, nociceptive specific (NS) neurons, responded only to intense mechanical stimuli. Neurons of the second type, wide dynamic range (WDR) neurons, w...

BACKGROUND The effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model. METHODS Catheters were placed into the intrathecal space of male Sprague-Dawley rats. Postoperative pain was evoked by an incision to the plantar surface of a hind paw. Withdrawal thresholds was used as a nociceptive ...

Possible modulation of Brewer's yeast-induced nociception by centrally (icv) administered nitric oxide (NO) modulators, viz., NO synthase (NOS) inhibitors, NO precursor, donors, scavengers and co-administration of NO donor (SIN-1) with NOS inhibitor (L-NAME) and NO scavenger (Hb) was investigated in rats. Administration of NOS inhibitors and NO scavenger Hb increased the pain threshold capacity...