Nuclear Magnetic Resonance serves as an important technique in many fields, including medicine (where it is known as MRI), chemical spectroscopy, and even quantum computation research. At its most basic, NMR is about the coherent manipulation and observation of nuclear dipole moments. Our work here deals exclusively with the hydrogen nucleus, which, being merely one proton, is both the simplest...

A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules, and to be used for ligand-based and protein-based approaches. NMR can also provide important information about the interactions in a protein-l...

Abstract In this paper, the epoxy value of resin TDE-85 was measured by proton nuclear magnetic resonance ( 1 H-NMR) spectroscopy and tetraethylammonium bromide titration. Comparisons measurement results repeatability two methods show that NMR can be used to measure TDE-85. However, because high requirements for sample purity, when testing containing impurities, is worse than

NMR measurements for metabolic characterization of biological samples like cells, biopsies or plasma, may take several hours for advanced methods. Preanalytical issues, such as sample preparation and stability over the measurement time, may have a high impact on metabolite content, and potentially lead to misinterpretation. The aim of this study was therefore to investigate by 1H HR-MAS NMR the...

Widely used higher-dimensional Fourier transform (FT) NMR spectroscopy suffers from two major drawbacks: (i) The minimal measurement time of an N-dimensional FT NMR experiment, which is constrained by the need to sample N - 1 indirect dimensions, may exceed by far the measurement time required to achieve sufficient signal-to-noise ratios. (ii) The low resolution in the indirect dimensions sever...

The measurement of diffusion parameters like activation energies and translational jump rates of small cations plays a key role in materials science. Especially the in-depth investigation of Li diffusion in ionic conductors is of great interest, because suitable ionic conductors are needed for, e. g., the development of new secondary ion battery systems. As the standard tracer method is not app...

The distortionless enhancement by polarisation transfer (DEPT) nuclear magnetic resonance (NMR) technique, combined with magnetic resonance imaging (MRI), has been used to provide the first in situ spatially-resolved and quantitative measurement of chemical conversion and selectivity within a fixed-bed reactor using natural abundance 13C NMR.

This application note demonstrates non-uniform sampling (NUS) acquisition and processing for routine measurement of 2D NMR spectra using tools in Agilent VnmrJ 4 software. It shows that NUS techniques can be applied easily and reliably to small molecule NMR measurements, yielding 2D spectra with comparable digital resolution to those obtained by traditional linear sampling methods, typically wi...

We propose a new approach to the measurement of a single spin state, based on nuclear magnetic resonance (NMR) techniques and inspired by the coherent control over many-body systems envisaged by quantum information processing. A single target spin is coupled via the magnetic dipolar interaction to a large ensemble of spins. Applying radio frequency pulses, we can control the evolution so that t...