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BACKGROUND the T-786C polymorphism of the gene for endothelial nitric oxide synthase (eNOS) and superoxide anion production may reduce production and bioavailability of nitric oxide, affecting the degree of vasodilation. This effect can be reversed by exercise. OBJECTIVE to investigate the influence of aerobic training and T-786C polymorphism in the concentrations of nitric oxide metabolites ...

UNLABELLED Nitric oxide (NO) plays an important signaling role in all domains of life. Many bacteria contain a heme-nitric oxide/oxygen binding (H-NOX) protein that selectively binds NO. These H-NOX proteins often act as sensors that regulate histidine kinase (HK) activity, forming part of a bacterial two-component signaling system that also involves one or more response regulators. In several ...

OBJECTIVES To verify if an experimental model of alloxan-diabetic rats promotes oxidative stress, reduces nitric oxide bioavailability and causes vascular dysfunction, and to evaluate the effect of N-acetylcysteine (NAC) on these parameters. METHODS Alloxan-diabetic rats were treated or not with NAC for four weeks. Plasmatic levels of malondialdehyde (MDA) and nitrite/nitrate (NOx), the endot...

Hypercholesterolemia is a dominant risk factor for the development and progression of atherosclerosis and its related cardiovascular diseases. The present study aimed to explore the effects of simvastatin combined with vitamin E on diet-induced hypercholesterolemia in rats. In the present study, hypercholesterolemia was induced by feeding rats with cholesterol-rich diet for six weeks. Rats were...

introduction: cigarette smoking affects nitric oxide production. the aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (nox) concentration. methods: serum nox concentration was measured by the griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. subjects were selected from participants of tehran lipid and gluco...

AIM Portal hypertension is a common complication of liver cirrhosis and significantly increases mortality and morbidity. Previous reports have suggested that the compound thalidomide attenuates portal hypertension (PHT). However, the mechanism for this action is not fully elucidated. One hypothesis is that thalidomide destabilizes tumor necrosis factor α (TNFα) mRNA and therefore diminishes TNF...

abstract background: nitric oxide (no) is a molecule that incorporates in many physiological processes of female reproductive system. recent studies suggested the possible role of endothelial isoform of nitric oxide synthase (enos) enzyme in female infertility. objective: the aim of this study is to evaluate the expression of endothelial nitric oxide synthase in endometrial tissue of women with...

Introduction: Cigarette smoking affects nitric oxide production. The aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (NOx) concentration. Methods: Serum NOx concentration was measured by the Griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. Subjects were selected from participants of Tehran Lipid and Gl...

background: migraine is a chronic  neurological  disorder, characterized  by recurrent  moderate to severe headaches. worldwide migraine a=ects nearly 15%. studies suggest that genes involved in the production of nitric oxide (no) may act as genetic  factors for migraine. no synthase  3 (nos3) by expressing  enzyme nos regulates  endothelial  derived no. one  class of  medications   used  as  f...