A solid-phase extraction absorbent material based on poly (N-isopropylacrylamide-comethacrylic acidco-ethylene glycol dimethacrylate) [poly (NIPAAm-MAA-co-EDMA)] monolithic column was developed for the simultaneous determination of nitrendipine and nisoldipine from human urine. The morphology of monolithic column and pressure drop across the columns were characterized. The results showed excell...

Temperature-triggered copolymers are proposed for a number of bio-applications but there is no ideal material platform, especially for injectable drug delivery. Options are needed for degradable biomaterials that not only respond to temperature but also easily accommodate linkage of active molecules. A first step toward realizing this goal is the design and synthesis of the novel materials repo...

We designed a kind of smart bioinspired fiber using the N-isopropylacrylamide (NIPAAm) polymer, with roughness and curvature features similar to those of wetted spider silk. The motion of tiny water droplets can be manipulated reversibly in directions by the effective cooperation of multi-gradients such as roughness, curvature and temperature-responsive wettability.

A near-infrared (NIR)-responsive Aurod@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The AuNRs and Aurod@pNIPAAm-PEGMA nanogel were characterized by UV-vis spectroscopy, Raman spectroscop...

Cells implanted after injury may remodel undesirably with improper mechanical stimulation from surrounding tissue. Proper conditioning of tissue engineered constructs before implantation can lead to suitable tissue architectures, along with an extracellular matrix (ECM) environment that more closely mimics native tissue. Additionally, cell implantation without bulky polymeric scaffolding is oft...

We report a new thermal targeting method in which a thermally responsive drug carrier selectively accumulates in a solid tumor that is maintained above physiological temperature by externally applied, focused hyperthermia. We synthesized two thermally responsive polymers that were designed to exhibit a lower critical solution temperature (LCST) transition slightly above physiological temperatur...