To prepare niosomes containing rifampicin were prepared using various nonionic surfactants of sorbitan ester class and cholesterol in 50:60 (1:1.2) percent mol fraction ratios for sustain release. To improve the dissolution rate of noisome are prepare handshaking method using Surfactants and cholesterol (150 μmol) in 50:60 (1:1.2) percent mol fraction ratio. The percent of drug estimated to be ...

Inflammatory processes play a crucial role in cardiovascular injury and disease. Inflamed endothelial cells express adhesion molecules which are potential therapeutic delivery targets for reducing or disrupting inflammation. We have developed non-ionic surfactant vesicles (niosomes) that are specifically targeted to inflamed vascular cells. Niosomes are self assembly vesicles that can encapsula...

Background. Cardiac ischemia is the major cause of morbidity and mortality which can be increased by Statins. This study aimed to increase effectiveness simvastatin in form niosomes. Methods. In this study, 25 male Wistar rats were divided into 5 groups: control, (induced closed LAD), receiving nano-niosomes, simvastatin, simvastatin-loaded nano-niosomes. One month after drug injection, RNA was...

Targeted drug-delivery systems are used for the administration of pharmaceutical medicament enables localization drugs to diseased sites. Different types uses carriers, like immunoglobulins, serum proteins, synthetic polymers, liposomes, nanoparticle and microspheres. Niosomes an emerging type novel vesicular systems. Now they being fervent explored as potential carriers targeted drug delivery....

We have previously reported a new preparation method for liposomes using supercritical carbon dioxide (scCO2) as a solvent, referred to as the supercritical carbon dioxide reverse phase evaporation (scRPE) method. In our previous work, addition of ethanol to scCO2 as a co-solvent was needed, because lipid molecules had to be dissolved in scCO2 to form liposomes. In this new study, niosomes (non...

Clotrimazole, an imidazole derivative antifungal agent is widely used for the treatment of mycotic infections of the genitourinary tract. In order to develop alternative formulation for the vaginal administration of clotrimazole to provide sustained and controlled release of appropriate drug for local vaginal therapy, liposomes/niosomes were evaluated as delivery vehicles. To optimize the prepa...

The objective of present study was to develop nonionic surfactant vesicles of proteolytic enzyme serratiopeptidase (SRP) by adapting reverse phase evaporation (REV) technique and to evaluate the viability of SRP niosomal gel in treating the topical inflammation. The feasibility of SRP niosomes by REV method using Span 40 and cholesterol has been successfully demonstrated in this investigation. ...

Norfloxacin is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Here we aiming to control the plasma concentrations of drug maintained throughout 24 h dosing interval with less peak trough fluctuation than that observed with twice daily dosing of immediate release norfloxacin. The short biological half-life (abou...

Niosomes have potential applications in topical drug delivery system. The objective of the study was to formulate and evaluate the niosome of Itraconazole. Surfactant : cholesterol ratio and quantity of ethanol used were studied by applying factorial design. Formulated niosomes were evaluated for vesicle size, entrapment efficiency, drug release, skin permeation, and antimycotic activity. Vesic...

Niosomes (nonionic surfactant-based vesicles) containing rifampicin were prepared using various nonionic surfactants of sorbitan ester class and cholesterol in 50:50 percent mol fraction ratio. The drug-entrapped vesicles were characterized for their shape, size, drug entrapment efficiency and in vitro release rate. On the basis of in vitro characterization, the niosomes showing maximum entrapm...