till date, most of the drugs have been given in conventional immediate release dosage form. nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...

For more than 10 years very satisfactory results have been obtained in the treatment of trichomonal vaginitis using the standard 7-day course of metronidazole 200 mg. three times a day (Rodin, King, Nicol, and Barrow, 1960). In a recent trial it was shown that a 5-day course of 400 mg. twice daily produced equally satisfactory results, and was probably an easier regime from the patient's point ...

For 10 years vaginal trichomoniasis has been treated by oral chemotherapy. Some cases appear not to respond satisfactorily to the drug used, and it is important to know whether or not the patient is taking the drug, and if so, whether or not it is being absorbed from the alimentary tract. A simple method for detecting these drugs in urine may be of use in such cases. Two antitrichomonal drugs i...

Trichomonas vaginalis (Tv) is a causative agent of worldwide spread sexually transmitted disease, particularly affecting underdeveloped all segments of the population. Metronidazole is by far the most prescribed drug for the treatment of trichomoniasis. However, the appearance of drug resistant has led to the appearance of new drug alternatives. That is why the development of reliable and stand...