The first line antihypertensive treatment for severe hypertension of pregnancy includes labetalol, hydralazine, or nifedipine. Rapid but safe blood pressure control allows the definitive treatment, delivery baby to be carried out with minimal delay and good maternal fetal outcomes. This non-randomized clinical trial was performed in Faridpur Medical College Hospital compare effectiveness tolera...

Introduction: Pregnancy increases the clearance of CYP3A4 substrate drugs and pregnancy-related hormones (PRHs) induce hepatic expression metabolism. However, it remains unclear to what extent magnitude PRH-evoked changes in CYP3A metabolism varies across multiple substrates. This study quantified impact PRHs on protein concentrations buprenorphine human hepatocytes, compared these effects nife...

Objectives: The purpose of this research work was to formulate and systemically evaluate in vitro performances polymeric microspheres nifedipine. Methods: Nifedipine containing two polymers, poloxamer 407 carbopol 934, were prepared by single emulsion cross-linking technique. Glutaraldehyde selected as the agent. A Box–Behnken design employed study effect independent variables, polymer concentr...

Nifedipine (NIF) a 1, 4-dihydropyridine calcium channel antagonist, undergoes photodegradation to nitroso analogues of dehydronifedipine (NDNIF) when exposed to sunlight. Photodegradation products of NIF have no clinical activity, so different formulations of NIF must remain unchanged. If NIF preparations become unstable in exposure to light, they could cause therapeutic failure. The present st...

four conformationally restricted analogues of pentamidine were prepared. then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/ml) of each compound and two positive controls (amphotericin b and pentamidine, 0.625 mg/ml), one negative control (culture medium) and one solvent control (dmso) were prepared and placed in 24-well plates containing 50000 parasite per well. promastigo...

To compare pregnancy latency achieved with oral labetalol versus extended-release nifedipine during expectant management of preterm preeclampsia severe features (PEC-SF). This is a retrospective cohort study patients initiated on antihypertensive therapy or admission for PEC-SF < 34 weeks between 1/2013 and 4/2022. Those prior to another indication delivery were excluded (monochorionic-monoamni...

Background: Preterm labor remains one of the major cause neonatal morbidity and mortality. Different tocolytics have been studied for prolongation pregnancy, role progesterone in increasing latency period controversial. Aim study was to compare efficacy nifedipine with along dydrogesterone as a tocolytic agent case preterm find its impact on maternal outcome. Methods: This conducted 100 women w...