Although the bacterium Xanthomonas pruni utilizes the classic "tryptophan pathway" to synthesize nicotinic acid (Wilson and Henderson, J. Bacteriol. 85:221, 1963), evidence is accumulating that most bacteria do not exhibit a tryptophan-nicotinic acid relationship. The absence of such a relationship in Escherichia coli and Bacillus subtilis was reported by Yanofsky (J. Bacteriol. 68:577, 1954). ...

Nicotinic acid has been used for decades to treat dyslipidaemic states. In particular its ability to raise the plasma HDL cholesterol concentration has led to an increased interest in its pharmacological potential. The clinical use of nicotinic acid is somewhat limited due to several harmless but unpleasant side effects, most notably a cutaneous flushing phenomenon. With the recent discovery of...

The ability of certain bacterial species to oxidize nicotinic acid was first reported by Allison (1) who used suspensions of bacteria isolated by Dubos and Miller (2). Koser and Baird (3) later isolated strains of Pseudomonas jluorescens which grew on a synthetic medium in which nicotinic acid was the sole carbon source. These strains did not attack isonicotinic acid, picolinic acid, or pyridin...

The growth and thermal stability of the gallic acid : nicotinic cocrystal has been analyzed in terms electron density analysis conversion GA monohydrate into anhydrate through heating co-crystal.

Although in vitro studies have shown that nicotinic acid inhibits some aspects of the inflammatory response, a reduced number of in vivo studies have investigated this activity. To the best of our knowledge, the effects induced by nicotinic acid in models of nociceptive and inflammatory pain are not known. Per os (p.o.) administration of nicotinic acid (250, 500 or 1000 mg/kg, -1 h) inhibited t...

ICOTINIC ACID and its derivatives occur in biologic materials as nicotinic acid, as nicotinamide, and in two co-enzymatic forms: diphosphopyridine nucleotide (DPN), and triphosphopyridine nucleotide (TPN). Among mammals, only man and dog are known to develop syrnptoms of nicotinic acid deficiency. In man, deficiency results in dermatitis, diarrhea, delirium, and death. Recently, nicotinic acid ...

In Escherichia coli, the nicotinamide moiety of pyridine nucleotides may be derived from de novo synthesis of the pyridine ring or through the uptake of either nicotinic acid or nicotinamide. De novo synthesis is the least preferred pathway; it is suppressed if an exogenous source is available. Nicotinamide is kinetically preferred over nicotinic acid; the data are consistent with the hypothesi...

Nicotinic acid is outstanding among the B vitamins in that its metabolic fate has been very extensively investigated. These studies, however, have been carried out mostly in higher animals, and they have revealed that (i) N'-methylnicotinamide is, in general, the major end-product of the metabolism of both nicotinic acid and nicotinamide; (ii) nicotinuric acid, the glycine conjugate of nicotini...

In a previous report (I) it was demonstrated that chicks receiving purified rations low in nicotinic acid grew poorly and developed a typical chick blacktongue. The occurrence of these symptoms was prevented by the addition of nicotinic acid to the ration. This paper presents further studies on this deficiency and gives data on the activity of several nicotinic acid esters, as well as studies o...

OBJECTIVE Nicotinic acid (also known as niacin or vitamin B3), widely used to treat dyslipidemias, represents an effective and safe means to reduce the risk of mortality from cardiovascular disease. Nonetheless, a substantial fraction of patients discontinue treatment because of a strong side effect of cutaneous vasodilation, commonly termed flushing. In the present study, we tested the hypothe...