Han, Bing, Baoan Ji, and Craig D. Logsdon. CCK independently activates intracellular trypsinogen and NF-kB in rat pancreatic acinar cells. Am J Physiol Cell Physiol 49: C465–C472, 2001.—In the cholecystokinin (CCK) hyperstimulation model of acute pancreatitis, two early intracellular events, activation of trypsinogen and activation of nuclear factor-kB (NF-kB), are thought to be important in th...

Fas-associated death domain protein (FADD), caspase-8-related protein (Casper), and caspase-8 are components of the tumor necrosis factor receptor type 1 (TNF-R1) and Fas signaling complexes that are involved in TNF-R1and Fas-induced apoptosis. Here we show that overexpression of FADD and Casper potently activates NF-kB. In the presence of caspase inhibitors, overexpression of caspase-8 also ac...

NF-kB transcription factors have been suspected to be involved in cancer development since their discovery because of their kinship with the v-Rel oncogene product. Subsequent work led to identification of oncogenic mutations that result in NF-kB activation in lymphoid malignancies, but most of these mutations affect upstream components of NF-kB signaling pathways, rather than NF-kB family memb...

Purpose: Activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) is an aggressive, poorly chemoresponsive lymphoid malignancy characterized by constitutive canonical NF-kB activity that promotes lymphomagenesis and chemotherapy resistance via overexpression of antiapoptotic NF-kB target genes. Inhibition of the canonical NF-kB pathway may therefore have therapeutic relevance in ABCDLBCL. Her...

In this study we investigated the effect of NF-kB signaling blockade on polymethylmethacrylate (PMMA) particle-induced osteoclastogenesis in vitro. We first established effective blockade of NF-kB activity as tested by electrophoretic mobility shift assays (EMSA). Particle-induced NF-kB activation in murine osteoclast precursor cells (CSF-1-dependent bone marrow macrophages) was markedly reduce...

Previous studies addressing functional aspects of nuclear factor KB (NF-KB) activation in normal and transformed keratinocytes revealed complex and seemingly contradictory roles of this transcription factor in this cell type. In normal skin, NF-KB signaling seems to inhibit squamous cell carcinoma development whereas, in squamous cell carcinoma themselves, deregulated NF-KB expression and/or si...

The transcription factor nuclear factor-kB (NF-kB) plays a pivotal role in the coordinated transactivation of cytokine and adhesion molecule genes involved in endothelial activation. Although recent reports have documented the contribution of NF-kB to apoptosis, it is still controversial. Especially, the role of NF-kB in endothelial apoptosis is largely unknown. Hypoxia significantly induced hu...

Patients with Type 2 diabetes often experience chronic inflammation due to the overexpression of NF-kB-regulated pro-inflammatory proteins, such as TNF-alpha, IL-6 and IL-1. Chaya (Cnidoscolus aconitifolius) extracts have been reported decrease this expression, but fractions these not studied. The present work focused on determining anti-inflammatory effect aqueous chaya. phenolic content sampl...

Nuclear factor-kB (NF-kB) is a family of highly regulated dimeric transcription factors that play pivotal roles in inflammatory responses and immunological reactions. Although they are often activated concurrently, classical and alternative NF-kB activation pathways have distinct regulatory functions, producing secondary inflammatory responses and regulating lymphoid organ development, respecti...

Nuclear factor-kB (NF-kB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kB mainly occurs via IkB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkBa. Optimal induction of NF-kB target genes also requires phosphorylation of NF-kB proteins, such as p65, within their transactivation domain by...