Exposure of rabbit reticulocytes to agents which damage the cell membrane by a variety of different mechanisms stimulates the incorporation of radioactive acetate and glycerol into membrane lipids. An increase in the rate of lipid synthesis occurs within minutes at 37’C at concentrations of the agents which do not cause spontaneous cell lysis. Different agents do not increase synthesis of diffe...

Thrombostasin (TS) is a previously characterized anticlotting protein with multiple isoforms found in the saliva of horn flies. In this report, the effect of TS isoforms on blood feeding was assessed using individual flies that carried corresponding ts allelles. Laboratory studies of horn fly blood feeding were conducted using colony-reared flies fed on New Zealand White (NZW) rabbits. After ti...

ultrasonographic examination of urinary system (kidney and urinary bladder) was conducted in new zealand white rabbit [nzwr] and tolai hare (lepus tolai). ultrasound images of the kidney and urinary bladder were evaluated on fifteen healthy rabbits of new zealand white rabbit and another fifteen tolai hares. the healthy rabbits were 8-12 months old (mean = 9.3 months), of both sexes and weighed...

Our understanding of the pathogenesis mechanisms leading to lupus has been augmented by the analysis of several diff erent murine models over the past four decades. Various mouse models of spontaneous lupus have been employed in an eff ort to understand the cellular and genetic mechanisms behind induction of systemic lupus erythematosus (SLE). Th e classic models of spontaneous lupus include th...

New Zealand Black (NZB) and New Zealand White (NZW) mice are genetically predisposed to a lupus-like autoimmune syndrome. To further define the loci linked to disease traits in NZB and NZW mice in the context of the BALB/c genetic background, linkage analyses were conducted in two crosses: (NZW x BALB/c.H2(z))F(1) x NZB and (NZB x BALB/c)F(2). Novel loci linked to autoantibody production and gl...

The lupus-prone New Zealand Black (NZB) strain uniquely develops a genetically imposed severe spontaneous autoimmune hemolytic anemia (AIHA) that is very similar to the corresponding human disease. Previous studies have mapped anti-erythrocyte Ab (AEA)-promoting NZB loci to several chromosomal locations, including chromosome 4; however, none of these have been analyzed with interval congenics. ...

F1 hybrids of New Zealand black (NZB) and New Zealand white (NZW) mice are a model of human systemic lupus erythematosus. These mice develop a severe immune com-plex-mediated nephritis, in which antinuclear autoantibodies are believed to play the major role. We used a genetic analysis of (NZB x NZW)F1 x NZW backcross mice to provide insight into whether different autoantibodies are subject to s...

Unlike parental New Zealand Black (NZB) or New Zealand White (NZW) mice, (NZB x NZW)F1 mice exhibit a lupus-like disease characterized by IgG autoantibody production and severe immune complex-mediated nephritis. In studies of the genetic susceptibility to disease in this F1 model, the NZW MHC (H2z) has been strongly linked with the development of disease, and it was hypothesized that class II M...