paraneoplastic cerebellar degeneration is a rare, fatal neuronal syndrome associated with ovarian, breast and lung cancers. anti-yo antibody mediated paraneoplastic cerebellar degeneration is known to be associated with gynecological malignancies, especially ovarian cancer. however, there are no reports of anti-yo antibody associated predominant peripheral mixed sensory and motor neuropathy in ...

I n a prior communication we demonstrated that transection of the optic nerve of the cat with consequent retrograde neuronal degeneration did not lead to alteration of the ipsilateral retinal vasculature. We interpreted this to mean that retinal neuronal degeneration does not, of itself, cause an associated vascular degeneration. In the present study the vasculature of the optic disc region of ...

One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systema...

Axon degeneration is a hallmark of several central nervous system (CNS) disorders, including multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). Previous neuroprotective approaches have mainly focused on reversal or prevention of neuronal cell body degeneration or death. However, experimental evidence suggests that mechanisms of axon degeneration may differ from cell...

Glia perform several energy-dependent functions that may aid neuronal survival under pathological conditions. Glycogen is the major energy reserve in brain, and it is localized almost exclusively to astrocytes. Using murine cortical cell cultures containing both glia and neurons, we examined the effect of altered glial glycogen stores on neuronal survival following glucose deprivation. As previ...