Background: Food-born botulism is caused by ingestion of contaminated food with clostridium botulinum neurotoxin. Case: In food-born botulism, due to acetylcholine release blockade, neuromuscular signs and symptoms are common, but in this case report we present a food-born botulism with papiledema and venous sinus thrombosis. Conclusion: Papiledema and fever could not rule out the diagnosis...

Neuromuscular blockade is a pharmacological adjunct for anesthesia and for surgical interventions. Neuromuscular blockers can facilitate ease of instrumentation and reduce complications associated with intubation. An undesirable sequela of these agents is residual neuromuscular blockade. Residual neuromuscular blockade is linked to aspiration, diminished response to hypoxia, and obstruction of ...

The influence of bile salts on the duration of action of the steroidal non-depolarizing neuromuscular blocking agent ORG 6368 was investigated in cats. The intravenous administration of ORG 6368 (100 microgram/kg body wt) caused a maximum neuromuscular blockade of 71 +/- 6% with a duration of action of 3.4 +/- 0.1 min. However, intraportal administration of the same dose caused no significant n...

Sugammadex is the first selective relaxant binding agent. It allows rapid reversal of any degree of neuromuscular blockade induced by steroidal neuromuscular blocking agents. Sugammadex acts by encapsulation of the neuromuscular blocking agent. This prevents the drug from acting on prejunctional and postjunctional nicotinic receptors, allowing acetylcholine to activate these receptors, and resu...

AN initial transient increase in the size of the muscle twitch before the onset of paralysis has been described as characteristic following the intravenous injection of a depolarizing neuromuscular blocking agent. During several series of experiments undertaken in the study of different aspects of neuromuscular block this typical response was confirmed, but it was also noted that occasionally a...